نتایج جستجو برای: dastjerdi

تعداد نتایج: 23  

Journal: :Chem 2021

New means for activating covalent bonds in organic compounds are crucial further advancing application fields from pharmaceuticals to plastics syntheses. The manufacturing of almost every daily product can be impacted by the development such bond activations. However, traditional catalysts these transformations faced with challenges as catalyst stability, recyclability, or energy demand. Due th...

Journal: :Cell chemical biology 2021

•CAR-IKZF3 degron expression and CART activity can be regulated in vitro•IMiD treatment controls CART-IKZF3 anti-tumor efficacy vivo•Such strategy aims to mitigate potential toxicities associated with therapy•The IKZF3/lenalidomide pair is portable other membrane proteins The recent development of successful CAR (chimeric antigen receptor) T cell therapies has been accompanied by a need better ...

2005
Nikos Logothetis Leila Reddy Itzhak Fried Eero P. Simoncelli Liz Bauer Joseph LeDoux Karim Nader Andrea Benucci Robert A. Frazor Matteo Carandini Daniel A. Butts Garrett B. Stanley Gal Chechik Eric D. Young Naftali Tishby Israel Nelken Mike Anderson O. Bar-Yosef Mark M Churchland Byron M. Yu Stephen I. Ryu Gopal Santhanam Afsheen Afshar Krishna V. Shenoy Nathaniel D. Daw Yael Niv Peter Dayan David McAlpine Anthony M. Zador

The control of circadian rhythms in the mammalian brain can be localized to a brain region known as the suprachiasmatic nucleus (SCN). The SCN consists of approximately 20,000 neurons whose firing rates oscillate on an approximately 24 hour rhythm. A large portion of these neurons are capable of maintaining a circadian rhythm in isolation in vitro. The firing rate of each neuron seems to be dri...

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