Deep brain stimulation (DBS) has become an important treatment option for carefully screened medication resistant neurological and neuropsychiatric disorders. DBS therapy is not always applied deep to the brain; does not have to be applied exclusively to the brain; and the mechanism for DBS is not simply stimulation of structures. The applications and target locations for DBS devices are rapidl...

Innovations in the field of deep brain stimulation (DBS) are introduced recently, considering that the fundamentals of DBS remained significantly unchanged over 25 years. Technological advances involve not only DBS hardware but also new patterns of stimulation, brain imaging and pathophysiological pathways. Every effort is done to obtain the best outcome for the patient with the lower adverse e...

obsessive-compulsive disorder (ocd) is a psychiatric disorder manifested by thoughts and impulses that produce anxiety and result in patients performing repetitive rituals. treatment generally consists of cognitive behavioral intervention and serotonin reuptake inhibitors. up to 40% of patients will have functional impairment that significantly affects their quality of life. in the late 1990’s,...

Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease (PD). The success of DBS is highly dependent on electrode location and electrical parameter settings. In this study patient-specific computer models of DBS were used for postoperative follow-up in three PD patients who suffered from stimulation induced hypomania, dysarthria, and uncontrollable laughter respectively...

Abstract Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the neurophysiological mechanisms of DBS remain unclear. We performed high-speed membrane voltage fluorescence imaging individual hippocampal CA1 neurons during delivered at 40Hz or 140Hz, free electrical interference, in awake mice. discovered that reliably depolarizes somatic potentials without suppressing spike...

Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus pallidus internus, both of which uniformly i...

OBJECTIVE Studies of bimanual actions similar to activities of daily living (ADLs) are currently lacking in evaluating fine motor control in Parkinson's disease patients implanted with bilateral subthalamic deep brain stimulators. We investigated basic time and force characteristics of a bimanual task that resembles performance of ADLs in a group of bilateral subthalamic deep brain stimulation ...

Some reports have demonstrated that deep brain stimulation (DBS) is a promising treatment for patients who suffer from intractable anorexia nervosa. However, the nature of DBS may not be viewed as a standard clinical treatment option for anorexia nervosa because of the unpredictable outcome before DBS. Just like DBS in the brain, electroacupuncture at acupoints is also efficient in treating ref...

abstract introduction: it is demonstrated that the degree of clinical improvement in parkinson's disease (pd) achieved by deep brain stimulation (dbs) is largely dependent on the accuracy of lead placement. in addition, individual variability in the situation of subthalamic nucleus (stn) is responsible for spatial inter-individual fluctuations of the real patient's target. objective: our study ...

Deep-brain stimulation (DBS) is an emerging research topic aiming to improve the quality of life patients with brain diseases, and a great deal effort has been focused on development implantable devices. This paper presents low-noise amplifier (LNA) for acquisition biopotentials DBS. electronic module was designed in low-voltage/low-power CMOS process, targeting applications. The measurement re...