BACKGROUND Modern radiotherapy (RT) reduces the side effects at organ at risk. However, skin toxicity is still a major problem in many entities, especially head and neck cancer. Some substances like chemotherapy provide a risk of increased side effects or can induce a "recall phenomenon" imitating acute RT-reactions months after RT. Moreover, some phototoxic drugs seem to enhance side effects o...

BACKGROUND Deep tissues and their afferents have unique responses to various stimuli and respond to injury distinctively. However, the types of receptors and endogenous ligands that have a key role in pain after deep tissue incision are unknown. TRPA1 has been shown to mediate pain-related responses in inflammation- and nerve injury-induced pain models. We hypothesized that TRPA1 has an importa...

An angiosome is a composite block of tissue that is supplied anatomically by source (segmental or distributing) vessels that span between the skin and bone. In addition to supplying the deep tissues, the source vessels of these angiosomes supply branches to the overlying skin, which pass either between the deep tissues or through the deep tissues, usually muscle, to pierce the outer layer of th...

Differentiating melanocytic from non-melanocytic (MnM) skin lesions is the first and important step required by clinical experts to automatically diagnosis pigmented skin lesions (PSLs). In this paper, a new clinically-oriented expert system (COE-Deep) is presented for automatic classification of MnM skin lesions through deep-learning algorithms without focusing on preor post-processing steps. ...

warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. most patients develop this complication at the initiation of therapy. the complication is ‎usually associated with an underlying thrombophilia. here we describe a case of a 75 year old ‎patient who developed skin necrosis in her both breasts during warfarin treatment for a ‎deep vein thrombosi...