Functional pathology of the default mode network is posited to be central to social-cognitive impairment in autism spectrum disorders (ASD). Altered functional connectivity of the default mode network's midline core may be a potential endophenotype for social deficits in ASD. Generalizability from prior studies is limited by inclusion of medicated participants and by methods favoring restricted...

Deactivation refers to increased neural activity during low-demand tasks or rest compared with high-demand tasks. Several groups have reported that a particular set of brain regions, including the posterior cingulate cortex and the medial prefrontal cortex, among others, is consistently deactivated. Taken together, these typically deactivated brain regions appear to constitute a default-mode ne...

The default mode network is a functionally connected network of brain regions that show highly synchronized intrinsic neuronal activation during rest. However, less is known about the structural connections of this network, which could play an important role in the observed functional connectivity patterns. In this study, we examined the microstructural organization of the cingulum tract in rel...

Recently, analyses of fMRI data have revealed functionally connected and interacting spontaneous active regions in the brain, which are referred as ”Default Mode Brain Network”. The fluctuations on BOLD signals of the default mode brain network have shown spatiotemporally correlated synchronization at a rate lower than 0.1 Hz in contrast to signals under concrete tasks like high frequency rhyth...

Functional imaging studies have shown reduced activity within the default mode network during attention-demanding tasks. The network circuitry underlying this suppression remains unclear. Proposed hypotheses include an attentional switch in the right anterior insula and reciprocal inhibition between the default mode and attention control networks. We analyzed resting state blood oxygen level de...

The pathophysiology of episodic memory dysfunction after infarction is not completely understood. It has been suggested that infarctions located anywhere in the brain can induce widespread effects causing disruption of functional networks of the cortical regions. The default mode network, which includes the medial temporal lobe, is a functional network that is associated with episodic memory pr...

Recent neuroimaging studies have shown that several brain regions--namely, the posterior cingulate cortex (PCC), ventral medial prefrontal cortex (vmPFC), and the bilateral angular gyrus--are more active during resting states than during cognitive tasks (i.e., default mode network). Although there is evidence showing that the default mode network is associated with unconscious state, it is uncl...

The default-mode network has been reported to possess highly versatile and even contrasting functions but the underlying functioning mechanism remains elusive. In this study, we adopt a dynamic view of the default-mode network structure and hypothesize that it could potentially contribute to different functions through dynamic reorganization of its functional interaction pattern within and acro...