BACKGROUND AND PURPOSE Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. METHODS ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first part of study, the time course of edema formation was determined. In the se...

Brief (15-minute) coronary occlusion and subsequent reperfusion lead to prolonged functional and metabolic abnormalities (stunned myocardium). Previous work suggests that one factor responsible for this phenomenon is oxygen-derived free radicals. The formation of the highly reactive hydroxyl radical requires the presence of metal ions, most importantly iron. In the present study, the effect of ...

BACKGROUND In thalassemia major (TM), severe cardiac siderosis can be treated by continuous parenteral deferoxamine, but poor compliance, complications and deaths occur. Combined chelation therapy with deferiprone and deferoxamine is effective for moderate myocardial siderosis, but has not been prospectively examined in severe myocardial siderosis. METHODS T2* cardiovascular magnetic resonanc...

BACKGROUND Iron may play a central role in oxygen radical generation during myocardial ischemia and after reperfusion. Because conditions during ischemia may also liberate iron, we hypothesized that administration of the iron chelator deferoxamine during ischemia would result in improved functional and metabolic recovery after postischemic reperfusion. METHODS AND RESULTS Isolated, perfused r...

In this research, for the first time in Iran, Deferoxamine test for differential diagnosis between Staph. epidermidis and Staph. hominis of other gram­positive cocci is introduced. Besides, the comparative results of the susceptibility rates of Staph. aureus (220 Spp.) and Enterococci ( 110 Spp.) to a new glycopeptide antibiotic (SK&Fl04662) and other 12 antibiotics are presented by Disk-Agar D...

Five new multifunctional Pt(iv) prodrugs with a carboplatin core and one or two axial deferoxamine ligands were synthesized. The complexes express multiple effects, including cytotoxicity high affinity towards ferric ions.

Introduction: Deferoxamine mesylate increases hypoxia inducible factor-1 alpha transactivation by preventing iron-catalyzed reactive oxygen stress, so it can be used to improve diabetic ulcer healing. This study was undertaken develop and physicochemical properties of topical deferoxamine-loaded solid lipid nanoparticles.
 Method: Solid nanoparticles were prepared using cold homogenization...

M ucormycosis is an uncommon acute and often fatal opportunistic fungal infection that usually occurs in patients with poorly controlled diabetes mellitus, acute leukemias, or other immunosuppressive conditions [1,2]. A new association, that of mucormycosis occurring in patients receiving deferoxamine therapy for iron or aluminum excess, has been reported with increasing frequency since 1986 [3...

Eleven minutes of complete cerebral ischemia was produced in 17 dogs by temporary ligation of the venae cavae and aorta. Immediately prior to the ischemic episode, 7 dogs received deferoxamine, an iron chelator, 50 mg/kg i.v., and 10 dogs received an equivalent volume of saline placebo i.v. Five dogs failed to meet preestablished protocol criteria and were excluded from data analysis. Neurologi...

BACKGROUND AND PURPOSE This study investigated if acute and delayed deferoxamine treatment attenuates long-term sequelae after germinal matrix hemorrhage (GMH). METHODS Bacterial collagenase (0.3 U) was infused intraparenchymally into the right hemispheric ganglionic eminence in P7 rat pups to induce GMH. GMH animals received either deferoxamine or vehicle twice a day for 7 consecutive days. ...