BACKGROUND AND AIMS The effect of adiponectin on colorectal carcinogenesis has been proposed but not fully investigated. We investigated the effect of adiponectin deficiency on the development of colorectal cancer. METHODS We generated three types of gene-deficient mice (adiponectin-deficient, adiponectin receptor 1-deficient, and adiponectin receptor 2-deficient) and investigated chemical-in...

The effect of dietary tyrosine and phenylalanine on survival of adult female C57BL/6 x DBA/2 F, mice bearing i.p. slowgrowing, moderately pigmented and fast-growing, highly pigmented B16 melanoma tumors was studied alone and in com bination with carbidopa-levodopa methyl ester chemotherapy. These studies tested three different diets: a natural product diet containing 1.09% phenylalanine and 0.6...

The influence of the source of dietary Fe (ferric citrate alone or mixed with bovine blood at a proportion of 1:1 (v/v)) on the digestive utilization of Fe, P, Ca and Mg, and on haemoglobin regeneration efficiency (HRE) was investigated in control and Fe-deficient rats. Diet A contained (by analysis) 43.5 mg Fe/kg diet (as ferric citrate), and diet B contained 44.3 mg Fe/kg diet (ferric citrate...

I . Weanling rats were fed on an iron-deficient diet without added folic acid and litter-mate controls received the same diet supplemented with Fe. Groups of deficient and control animals were killed at intervals of up to 88 days and glutamate formiminotransferase activity in liver and folic acid activity in liver and serum were measured. 2. No differences were found between the results from th...

An experiment was conducted to determine the effect of an essential fatty acid (EFA) deficient diet on growth, immune status and renal morphology of juvenile gilthead sea bream, using two diets: a control diet containing 2% (DW) of n-3 high unsaturated fatty acid (n-3 HUFA) and a diet formulated to be deficient in EFA for this species and containing 0.5% DW of n-3 HUFA (diet NFA). After 9 weeks...

An amino acid-defined, folate-deficient diet was used to investigate the regulation of pancreatic glycine N-methyltransferase in vivo. This enzyme modulates the ratio of S-adenosylmethionine to S-adenosylhomocysteine and is inhibited by bound folate in vitro. Rats were fed either a folate-deficient diet, a folate-supplemented diet (pair-fed to the deficient group), or a folate supplemented diet...

In order to clarify the effects of a high-calcium (Ca) diet on bone formation in magnesium (Mg)-deficient rats, this study focused on the effects of a high-Ca diet on serum insulin-like growth factor-1 (IGF-1) levels. Male rats were randomized by weight into four groups, and fed one of four experimental diets containing two different Mg concentrations (0.05% (normal-Mg) or Mg-free (Mg-deficient...

The pathogenesis of a Citrobacter rodentium infection was evaluated in mice fed diets with a single deficiency in either selenium or vitamin E or with a double deficiency in both selenium and vitamin E compared to mice on nutritionally adequate diets. Mice fed the selenium- and vitamin E-deficient diet for 6 weeks had increased loads of C. rodentium in the colon and spleen, which were not obser...

The present study examined the effects of a tryptophan-deficient diet on behavioral and neurochemical response to amphetamine. A tryptophan-deficient diet (14 days) decreased striatal serotonin and 5-hydroxyindolacetic acid content in rats. Under the latter conditions, amphetamine increased dopamine efflux in striatum and nucleus accumbens and produced a greater increase in motor activity when ...