A Simple fast and precise reversed phase high performance liquid chromatographic method is developed for the Deflazacort drug. Chromatographic separation was performed a C18 column (250×4.6 mm) as a stationary phase with the mobile phase of Acetonitrile, methanol and water (90:5:5 v/v). Flow rate is 1.0 ml/min the detection of wave length is 230 nm. This method was validated for linearity, accu...

Prednisone or prednisolone are the mainstay drug treatments for autoimmune hepatitis in children. However, long-term use of corticosteroid is associated with the risk of steroid-induced toxicities, and this situation requires newer immuno-suppressive agents for the treatment of autoimmune hepatitis, especially in growing children. An 11-yr-old Korean girl with type-1 autoimmune hepatitis discon...

Purpose: In February 1988, 66 patients (98 eyes) affected with solar retinopathy due to sun gazing during the same religious ritual were observed at the University Eye Clinic of Chieti. Methods: At baseline a complete functional and morphological examination was performed. During a 7 years follow-up patients underwent functional control visits. After 7 years 32 out of 66 patients (57 eyes) were...

Purpose: In February 1988, 66 patients (98 eyes) affected with solar retinopathy due to sun gazing during the same religious ritual were observed at the University Eye Clinic of Chieti. Methods: At baseline a complete functional and morphological examination was performed. During a 7 years follow-up patients underwent functional control visits. After 7 years 32 out of 66 patients (57 eyes) were...

We randomized 18 Duchenne muscular dystrophy (DMD) boys whose age ranged from 5.2 to 14.6 years (mean, 7.3 years) for treatment with either deflazacort (0.9 mg/kg/day) or prednisone (0.75 mg/kg/day) on the basis of age and functional score at the onset of treatment. We followed the patients every 3 months for 1 year, evaluating four limb muscles with the Medical Research Council scale and perfo...

Purpose: In February 1988, 66 patients (98 eyes) affected with solar retinopathy due to sun gazing during the same religious ritual were observed at the University Eye Clinic of Chieti. Methods: At baseline a complete functional and morphological examination was performed. During a 7 years follow-up patients underwent functional control visits. After 7 years 32 out of 66 patients (57 eyes) were...

Four groups of mdx mice (deflazacort, high dose of 1.5 mg/kg and low dose of 0.75 mg/kg; prednisone, 1.0 mg/kg; and a placebo) were examined in a double-blind protocol. The experiments tested the hypothesis that infrared spectroscopy can distinguish among gastrocnemius muscle tissues derived from dystrophic animals (n = 22) from different treatment groups and from control muscle tissue (n = 23)...

Data reported here were collected over an 8-year period for 79 Duchenne muscular dystrophy patients, 37 of whom were treated with deflazacort. Mean length of treatment was 66 months. Treated boys stopped walking at 11.5 +/- 1.9 years, compared with 9.6 +/- 1.4 years for untreated boys. Cardiac function was better preserved with the use of deflazacort, as shown by a normal shortening fraction in...

Purpose: In February 1988, 66 patients (98 eyes) affected with solar retinopathy due to sun gazing during the same religious ritual were observed at the University Eye Clinic of Chieti. Methods: At baseline a complete functional and morphological examination was performed. During a 7 years follow-up patients underwent functional control visits. After 7 years 32 out of 66 patients (57 eyes) were...