Dehydroepiandrosterone, an adrenal hormone derived from cholesterol, can be metabolized to estrogens (estradiol) and androgens (testosterone). In this study, we evaluated whether the antiproliferative effect induced by dehydroepiandrosterone in MCF-7 cells (an estrogen-dependent breast cancer cell line) is direct, or indirect, through its conversion to estradiol or testosterone. Although dehydr...

Dehydroepiandrosterone and dehydroepiandrosterone sulfate are en dogenous steroids largely produced in the adrenal cortex and excreted in the urine. Many studies have demonstrated that administration of dehy droepiandrosterone to animals protects against a variety of chemical carcinogens. Kpidemiological studies suggest that the circulating levels of these steroids in humans are related to the ...

We evaluated the reproducibility of plasma hormone levels over time in 79 healthy postmenopausal women, ages 51-69 years at baseline, who were not using postmenopausal hormones. Three blood samples were collected between 1989 and 1992 from each of these women. We assessed plasma levels of estradiol, free estradiol, percentage of free estradiol, bioavailable estradiol, percentage of bioavailable...

Although the incidence of gastric cancer varies widely between countries it is nonetheless a leading cause of cancer deaths worldwide. Migration studies indicate that dietary choices are an important exogenous factor. The United States has a very low incidence of gastric cancer, suggesting that exogenous etiological agents are at a minimum and providing a favorable setting for detecting importa...

}lomogenates of testes from human fetuses of 12-16 weeks gestation were incubated in vitro with pregnenolone-4-14C and pregnenolone-7-3Hsulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearin~ the tritium label only, were identified in the conjugated fraction. Progesterone, 17~-hydroxyprogesterone, 17a-hydroxypregnenolone, dehydroepiandrosterone, androstenedione and testos...

OBJECTIVE This study aims to assess cortisol and dehydroepiandrosterone sulfate (DHEA-S) levels in post-menopausal women with FMS and correlate it with pain threshold and tolerance, depression and quality of life. METHODS We conducted a cross sectional observational study of 17 women with FMS (FMS group), and 19 healthy volunteers (CT group). Algometry, the Beck Depression Index (BDI) and Fib...