In today’s globalization, the success of an industry is dependent on cost effective supply chain management under various markets, logistics and production uncertainties. Uncertainties in the supply chain usually decrease profit, i.e. increase total supply chain cost. Demand uncertainty and constraints posed by the every echelon are important factors to be considered in the supply chain design ...

In this paper, a bi-objective pharmaceutical supply chain network under uncertainty demand and transportation costs is modeled and developed. To control the uncertainty parameters, the robust optimization method is considering. The main objective of this paper determines the number and location of potential facilities such as drug manufacture centers and drug distribution centers by considering...

In the era of meager profit, production costs often become an important factor affecting SMEs’ operating conditions, and how to effectively reduce production costs has become an issue of in-depth consideration for the business owners. Especially, the food and beverage (F&B) industry cannot accurately predict the demand. It many cause demand forecast fall and excess or insufficient inventory pre...

A centralized multi-echelon, multi-product supply chain network is presented in a multi-period setting with products that show varying demand against price. An important consideration in such complex supply chains is to maintain system performance at high levels for varying demands that may be sensitive to product price. In order to examine the price-centric behavior of the customers, the conce...

Background and Objectives: A sudden jump in blood demand during natural disasters may have strong negative impact on the performance of blood supply chain. Appropriate response to emergency situations requires predictive approach to determining the optimal allocation of blood supply chain resources for various disaster scenarios. The present study, thus, presents an optimization model aimed at ...

This paper studied pricing, service level, and production quantity decision problems in a supply chain with one manufacturer and one retailer under demand and production cost disruptions. The joint impact of demand and production cost disruptions on optimal pricing, service level, and production decisions in centralized and decentralized supply chain was analyzed, respectively. By solving the o...