We reviewed and compared the neuropathology of multiple sclerosis (MS), neuromyelitis optica (NMO), neuromyelitis optica spectrum disorders (NMOSD) and acute disseminated encephalomyelitis (ADEM) in Japan. Demyelinating lesions of MS are well circumscribed as compared with the lesions of NMO and NMOSD, which reveal variable, irregularly shaped and ill-defined borders that extend longitudinally ...

The term ' demyelinating diseases' is applied to a group of disorders of the central nervous system which show loss of the normal myelination of the white matter and in which this loss is regarded as being of especial importance. This paper is a short review of such conditions and it will also include a brief survey of recent research work which it is believed may throw light on them, particula...

The term ' demyelinating diseases' is applied to a group of disorders of the central nervous system which show loss of the normal myelination of the white matter and in which this loss is regarded as being of especial importance. This paper is a short review of such conditions and it will also include a brief survey of recent research work which it is believed may throw light on them, particula...