Down syndrome cell adhesion molecule, or DSCAM, has been implicated in many neurodevelopmental processes including axon guidance, dendrite arborization, and synapse formation. Here we show that DSCAM plays an important role in regulating the morphogenesis of cortical pyramidal neurons in the mouse. We report that DSCAM expression is developmentally regulated and localizes to synaptic plasma mem...

The capture efficiency of the small aerosol particle is strongly influenced by the structure of fibrous layers. This study presents particle deposition and dendrite formation on different arrangements of binary fibers. 2-D numerical simulation is performed using the open source software of OpenFOAM. In the instantaneous filtration of a single fiber, obtained results are in good agreement with th...

Dendrite, a typical geological pattern, is developed along the bedding plane in limestone and dolomite strata Jinzigou area, Zhoukoudian, Beijing, China, with self-similar dendritic morphology. In order to reveal dynamic mechanism of its formation, diffusion-limited aggregation method, model fractal growth, was selected simulate microscopic formation. Take an L × square lattice, = 200 lattices,...

Formation of neural circuits depends on stable contacts between neuronal processes, mediated by interaction of cell adhesion molecules, including N-cadherin. In the present study, we found that activity-dependent dendrite arborization specifically requires N-cadherin-mediated extracellular neuron-neuron interaction, because the enhancement did not occur for neurons cultured in isolation or plat...

High brilliance synchrotron X-ray radiography has been used to in situ study the solidification process of Al­20mass%Cu alloy with nominal spatial and temporal resolutions of 7.4 μm and 300ms, respectively. The block of favorably oriented dendrites by the unfavorably oriented ones was first observed in metal solidification, which related to solute interaction of neighbor dendrites. Solute inter...

The development of a highly branched dendritic tree is essential for the establishment of functional neuronal connections. The evolutionarily conserved immunoglobulin superfamily member, the protein dendrite arborization and synapse maturation 1 (Dasm-1) is thought to play a critical role in dendrite formation of dissociated hippocampal neurons. RNA interference-mediated Dasm-1 knockdown was pr...

Dendritic morphology determines many aspects of neuronal function, including action potential propagation and information processing. However, the question remains as to how distinct neuronal dendrite branching patterns are established. Here, we report that postsynaptic density-95 (PSD-95), a protein involved in dendritic spine maturation and clustering of synaptic signaling proteins, plays a n...

The proper formation and morphogenesis of dendrites is fundamental to the establishment of neural circuits in the brain. Following cell cycle exit and migration, neurons undergo organized stages of dendrite morphogenesis, which include dendritic arbor growth and elaboration followed by retraction and pruning. Although these developmental stages were characterized over a century ago, molecular r...

The dendritic trees of neurons result from specific patterns of growth and branching, and dendrite branches of the same neuron avoid one another to spread over a particular receptive field. Recognition molecules on the surfaces of dendrites influence these patterning and avoidance processes by promoting attractive, repulsive or adhesive responses to specific cues. The Drosophila transmembrane p...