Dentinogenesis Imperfecta (DI) or hereditary opalescent dentin is inherited in a simple autosomal dominant mode with high penetrance and low mutation rates. It generally affects both the deciduous and the permanent dentitions. DI corresponds to a localized form of mesodermal dysplasia which is observed in the histo-differentiation. An early diagnosis and treatment are therefore fundamental, whi...

introduction: this study was carried out to investigate calcific tissue formation against mineral trioxide aggregate (mta) after pulp capping. materials and methods: the pulps of six teeth from four dogs were exposed and capped with mta. after extraction each tooth was sectioned into halves. each half was then further sectioned in the mesiodistal or buccolingual direction. calcified tissue of t...

Pediatric Dentistry – 21:2, 1999 Abnormalities of dentin formation have been classified into two large categories: those that are primarily diseases of the dentin itself and those in which the dentin defect accompanies defects in other tissue systems. For example, the former category contains dentin dysplasia types I and II, dentinogenesis imperfecta types II and III and regional odontodysplasi...

We isolated dental papilla mesenchymal cells (DPMCs) from different rat incisor germs at the late bell stage and incubated them as cell pellets in polypropylene tubes. In vitro pellet culture of DPMCs presented several crucial characteristics of odontoblasts, as indicated by accelerated mineralization, positive immunostaining for dentin sialophosphoprotein and dentin matrix protein 1, and expre...

Many morphological and developmental studies have demonstrated the characteristics of tight junctions (TJs) between odontoblasts. However, detailed localization of TJ-associated proteins in odontoblasts and their functions has not yet been clarified. To elucidate the relationship between the establishment of TJ structures and the differentiation of odontoblasts during early dentinogenesis, we s...

normal pulp cavities exclude dentinogenesis imperfecta". In the dentine abnormalities that may be associated with osteogenesis imperfecta, the pulp chambers and root canals are either progessively obliterated by the continuous deposition of highly disorganised dentine, or the pulp chambers are larger than normal by a failure of deposition. It is not possible to ascertain whether or not the pulp...

A better understanding of the microstructure and mechanical properties enamel dentine may enable practitioners to apply current adhesive dentistry protocols clinical cases involving disorders (dentinogenesis imperfecta or dysplasia). Publications (up June 2020) investigating were browsed in a systematic search using PubMed/Medline, Embase Cochrane Library electronic databases. Two authors indep...