نتایج جستجو برای: dependent kinase
تعداد نتایج: 852230 فیلتر نتایج به سال:
IKK/NF-kB signalling controls inflammation and cell death is important to maintain tissue homeostasis. Keratinocyte-specific deletion of IKK2 (IKK2E-KO) leads TNFR1-dependent skin in mice. IKK2E-KO mice showed increased numbers apoptotic necrotic keratinocytes, upregulation inflammatory cytokines mediators the epidermis. We proposed that keratinocyte could trigger inflammation. Receptor Interac...
Machine learning methods are used to predict the inhibitory activity of compound targeting cyclin dependent kinase 4 (CDK4), and analyse fragment features CDK4 inhibitors.
Intracellular Ca2+ and protein phosphorylation play pivotal roles in long-term potentiation (LTP), a cellular model of learning and memory. Ca2+ regulates multiple intracellular pathways, including the calmodulin-dependent kinases (CaMKs) and the ERKs (extracellular signal-regulated kinases), both of which are required for LTP. However, the mechanism by which Ca2+ activates ERK during LTP remai...
Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes. This study was designed to investigate the effects of oxymatrine on nuclear factor–kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide (LPS)-activated microglia. In this paper, BV2...
Chronic rhinosinusitis is a chronic inflammatory condition that caused by many factors. However, the underlying mechanism of remains unclear. The current study focused on roles triptolide hydrogen peroxide treated nasal epithelial cells and underling mechanism. Hydrogen human were cultured different concentrations triptolide, cell growth death determined counting kit-8 flow cytometry methods. M...
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