Vitiligo is a depigmentation disorder; Reactive Oxygen Species (ROS) plays a major role in the development of depigmentation. Monoamine oxidase-A(MAO-A) enzyme is one of the reasons in producing ROS by metabolizing norepinephrine which found to be high level in vitiligo patients. Inhibiting MAO-A enzyme prevents further depigmentation. Clinical studies proved that the isoquinoline alkaloids hav...

Gingival health and appearance are essential components of an attractive smile. Gingival pigmentation results from melanoblastic activity. ‘Black gums’ are common esthetic problem particularly in patients who have a very high smile line (gummy smile). Different treatment modalities have been reported for depigmentation of gingiva such as bur abrasion, scraping, partial thickness flap, cryothera...

statement of the problem: melanin pigmentation of the gingiva is a crucial esthetic problem. a variety of methods have been used for gingival depigmentation. purpose: the purpose of this study was to compare the results of two treatment modalities: scalpel technique and cryotherapy with liquid nitrogen in treatment of gingival pigmentation. materials and method: twenty patients with chief compl...

A beautiful smile surely enhances the individual’s self-confidence. The harmony of is attributable to shape, color, and position teeth in conjunction with gingival tissue. Gingival pigmentation occurs all races man, varies from one race another & caused by a variety external endogenous sources. Excessive deposition melanocytic has significant impact on aesthetics also produces psychological...

The pathogenesis of vitiligo based on the model of depigmentation produced by topical application of phenolic compounds that are substrates for tyrosinase is outlined. The main steps in the pathway consist of the haptenation of melanosomal proteins by the quinone products of the analogue phenols with the generation of neo-antigens which are able to elicit a cell-mediated immune response that re...

BACKGROUND Although clinical melanin pigmentation does not present itself as a medical problem or a disease entity, "black gums" is a major esthetic complaint for many people, who often requests cosmetic corrections. Gingival depigmentation can be carried out using many procedures; lasers of various types being a new addition. This study was undertaken to evaluate and compare the effectiveness ...

Deregulated activation of the KIT receptor tyrosine kinase has been implicated in several human cancers and in inflammation, making it an attractive target for therapeutic intervention. Conversely, deficiencies in KIT signaling have been implicated in human and animal hair pigmentation disorders, reflecting a role for KIT in the development and function of melanocytes. The goal of this study wa...

Vitiligo is an acquired cutaneous depigmentation disorder which has a deleterious effect on the psychosexual function of many individuals; the genitalia are the common site for depigmentation. Here, the authors report two cases of focal vitiligo affecting the scrotum of the genital organs which were successfully treated by autologous cultured melanocyte transplantation. Autologous cultured mela...