Intraflagellar transport (IFT) moves multiple protein particles composed of two biochemically distinct complexes, IFT-A and IFT-B, bi-directionally within cilia and is essential for cilia assembly and maintenance. We identified an ORF from the Tetrahymena macronuclear genome sequence, encoding IFT122A, an ortholog of an IFT-A complex protein. Tetrahymena IFT122A is induced during cilia regenera...

background: pain control during and after surgeries can reduce subsequent complications, improve the recovery period of the patient after the surgery and immediately after discharge from the hospital, and shorten the length of stay in the hospital. objectives: the present research aimed to study the relationship between the depth of anesthesia and severity of pain after general anesthesia. meth...

Observations of the microtubular 'km' system and filamentous ' M ' systems in living specimens of Stentor coerulens show that on contraction of the body both systems shorten, thicken and remain straight, but that on initial relaxation they behave differently: the km fibres begin to lengthen later than the M fibres, the latter being thrown into sinuous folds. Electron microscopy of specimens coo...

We show that the standard stochastic gradient decent (SGD) algorithm is guaranteed to learn, in polynomial time, a function that is competitive with the best function in the conjugate kernel space of the network, as defined in Daniely et al. [13]. The result holds for log-depth networks from a rich family of architectures. To the best of our knowledge, it is the first polynomial-time guarantee ...

Elevated pCO2 threatens coral reefs through impaired calcification. However, the extent to which elevated pCO2 affects the distribution of the pelagic larvae of scleractinian corals, and how this may be interpreted in the context of ocean acidification (OA), remains unknown. We tested the hypothesis that elevated pCO2 affects one aspect of the behavior (i.e., motility) of brooded larvae from Po...

Systematic studies of phenotypic diversity--required for understanding evolution--lag behind investigations of genetic diversity. Here we develop a quantitative approach to studying behavioral diversity, which we apply to swimming of the ciliate Tetrahymena. We measure the full-lifetime behavior of hundreds of individual organisms at high temporal resolution, over several generations and in div...

1Department of Physics and Astronomy, University College London, Gower Street, LondonWC1E 6BT, UK 2Laboratoire d’Etudes Spatiales et d’Instrumentation en Astrophysique (LESIA), Observatoire de Paris, CNRS, UPMC Univ. Paris 06, Univ. Paris-Diderot, 5 place Jules Janssen, Meudon Cedex 92195, France 3Atmospheric, Oceanic and Planetary Physics, Clarendon Laboratory, University of Oxford, Parks Road...