A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth side-by-side studies are lacking. The aim of this study was to investigate the in vitro activities of PZQ and its main metabolites, namely, R- and S-cis-...

Brandeis University, Waltham, MA 02454 9 10 11 12 13 14 15 Running title: Activity regulates PSD-95-mediated synaptic strengthening 16 17 Correspondence: John E. Lisman 18 Biology Department and Volen Center for Complex Systems 19 Brandeis University, Waltham, MA 02454 20 E-mail: [email protected] 21 Phone: 781-736-3145 22 Fax: 781-736-3107 23 24 25 Articles in PresS. J Neurophysiol (November...

das thema „orient“ besch?ftigte schon lange vor der institutionalisierung der orientforschung und entstehung von orientalistikschulen die deutschsprachige kulturszene und wurde vor allem seit der zweiten h?lfte des 18. jahrhunderts mit einem ungeheuren illusorischen potenzial intensiver denn je in literarischen werken und ubersetzungen sowie in geistesgeschichtlichen debatten thematisiert. die ...

KP-736, a new cephen antibiotic with a broad antibacterial spectrum and potent antipseudomonal activity, was evaluated for in vitro antibacterial activity in comparison with ceftazidime, cefotaxime, and cefpirome. KP-736 was significantly more active than the test compounds against gram-negative bacteria, including the Pseudomonas group and ceftazidime-, cefotaxime-, or imipenem-resistant strai...

The iron hormone hepcidin is inhibited by matriptase-2 (MT2), a liver serine protease encoded by the TMPRSS6 gene. Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption. TMPRSS6 inactivation causes iron-deficiency anemia ref...

‎Let $L$ be a Lie algebra‎, ‎$mathrm{Der}(L)$ be the set of all derivations of $L$ and $mathrm{Der}_c(L)$ denote the set of all derivations $alphainmathrm{Der}(L)$ for which $alpha(x)in [x,L]:={[x,y]vert yin L}$ for all $xin L$‎. ‎We obtain an upper bound for dimension of $mathrm{Der}_c(L)$ of the finite dimensional nilpotent Lie algebra $L$ over algebraically closed fields‎. ‎Also‎, ‎we classi...

der folgende text, der unter der betreuung von herrn dr. touraj rahnema entstanden ist, erw?hnt zuerst kurz die bestimmenden züge der literarischen schule, die im europ?ischen kulturraum allgemein als romantik verstanden wird, will aber darüber hinaus die romantik als eine art lebenshaltung und kunstverst?ndnis begreifen, die unabh?ngig von einer bestimmten kunstperiode genauso auch in ?stliche...

‎let $l$ be a lie algebra‎, ‎$mathrm{der}(l)$ be the set of all derivations of $l$ and $mathrm{der}_c(l)$ denote the set of all derivations $alphainmathrm{der}(l)$ for which $alpha(x)in [x,l]:={[x,y]vert yin l}$ for all $xin l$‎. ‎we obtain an upper bound for dimension of $mathrm{der}_c(l)$ of the finite dimensional nilpotent lie algebra $l$ over algebraically closed fields‎. ‎also‎, ‎we classi...