1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress and animal welfare considerations. The original acute Dermal Toxicity Guideline TG 402 (1) was adopted in 1987. Development of a dermal Fixed Dose Procedure (FDP) was considered appropriate, following adoption of the revised Oral FDP, OECD Guideline 420 (2) and deletion of OECD Guidelin...

silver nanoparticles (ag nps) have been widely used as new potent antimicrobial agents in cosmetic and hygienic products. present study compares the tissue levels of ag nps in different organs of guiana pigs quantitatively after dermal application and analysis the morphological changes and pathological abnormalities on the basis of the ag nps tissue levels. before toxicological assessments,the ...

Aim: This study was conceived for the purpose of evaluating dermal toxicity potentials of extracts from S. glaucescens which is known for many traditional application in human and animals including healing wounds, boils, HIV, worms and application on the swollen lymph nodes of cattle suffering from east coast fever (ECF). This followed the scanty availability of information regarding Original R...

antibiotic resistance to microorganisms is one of the major problems faced in the field of wound care in burns patients. silver nanoparticles have come up as potent antimicrobial agent and are being evaluated in diverse medical applications ranging from silver based dressings to silver coated medical devices. we aimed in present study to test the release of nanosilver from nanosilver wound dres...

objective(s): nanomaterials, especially silver nanoparticles (ag-nps), are employed in an increasing number of commercial products. this has led to an ever growing exposure of human beings to this substance. the first purpose of the nano committee of food and drug administration of the islamic republic of iran (ifda) is developing guidelines to assess and approve commercial nano-health products...

background pomegranate (punica granatum) is a significant source of bioactive compounds. however, its toxicity is not intensively studied. objectives the current study investigated the safety and tolerability of pomegranate peel extract (ppe) in balb/c mice. conclusions the current study showed that ppe had no toxicity and its use is suggested with potential applications against diseases. resul...

Polymyxin B treated cell sonicates, cell-free supernatants and outer membrane proteins were prepared from animal-passed, virulence-enhanced strains and original isogenic strains of Cjejuni and tested for dermal toxicity in rabbits. Polymyxin B extracts produced the strongest lesions, but the outer membrane protein from 6 times mouse-passed strains elicited a mild skin reaction. Culture-supernat...

Objective(s): Nanomaterials, especially silver Nanoparticles (Ag-NPs), are employed in an increasing number of commercial products. This has led to an ever growing exposure of human beings to this substance. The first purpose of the Nano Committee of Food and Drug Administration of The Islamic Republic of Iran (IFDA) is developing guidelines to assess and approve commerci...

To clarify the health risks related to silver nanoparticles (Ag-NPs), we evaluated the genotoxicity, acute oral and dermal toxicity, eye irritation, dermal irritation and corrosion and skin sensitisation of commercially manufactured Ag-NPs according to the OECD test guidelines and GLP. The Ag-NPs were not found to induce genotoxicity in a bacterial reverse mutation test and chromosomal aberrati...

In recent years, it has become evident that it is necessary to systematically and accurately define particle characteristics in order to understand the potential toxicity of nanoparticles to biological systems. The properties that need to be emphasized are size, shape, dispersion, doping, aggregation, functionalization, physical and chemical properties, surface area, and surface chemistry. Rout...