Plakoglobin directly interacts with cadherins and plays an essential role in the assembly of adherens junctions and desmosomes. Recently we have reported that multiple cadherin binding sites are localized along the arm repeat region of plakoglobin. To demonstrate functionally and specificity of these sites in vivo we constructed a set of chimeric proteins containing a plakoglobin sequence fused...

background & objective: lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. desmogleins i and iii are the main desmosomal transmembrane proteins. these proteins have been identified as the autoantigen of the autoimmune disease. the aim of t...

Pemphigus is a group of autoimmune blistering diseases. There had been abundant evidence that antibodies against components within the desmosomes were responsible for its pathogenesis. The major antigens in pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 (130 kDa) and desmoglein 1 (160 kDa) respectively. They are glycoproteins belonging to the cadherin family and form part of the tr...

Citation: Seiffert-Sinha K, Khan S, Attwood K, Gerlach JA and Sinha AA (2018) Anti-Thyroid Peroxidase Reactivity Is Heightened in Pemphigus Vulgaris and Is Driven by Human Leukocyte Antigen Status and the Absence of Desmoglein Reactivity. Front. Immunol. 9:625. doi: 10.3389/fimmu.2018.00625 anti-Thyroid Peroxidase reactivity is heightened in Pemphigus Vulgaris and is Driven by human leukocyte a...

RATIONALE The sympathetic nervous system is a major mediator of heart function. Intercalated discs composed of desmosomes, adherens junctions, and gap junctions provide the structural backbone for coordinated contraction of cardiac myocytes. OBJECTIVE Gap junctions dynamically remodel to adapt to sympathetic signaling. However, it is unknown whether such rapid adaption also occurs for the adh...

Cell adhesion and communication are interdependent aspects of cell behavior that are critical for morphogenesis and tissue architecture. In the skin, epidermal adhesion is mediated in part by specialized cell-cell junctions known as desmosomes, which are characterized by the presence of desmosomal cadherins, known as desmogleins and desmocollins. We identified a cadherin family member, desmogle...

© 2014 The Authors. doi: 10.2340/00015555-1811 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Pemphigus is an autoimmune intraepidermal blistering disease (1). The autoimmune target of the antibodies is desmoglein, a cadherin-like cell-to-cell adhesion molecule found in desmosomes. In pemphigus vulgaris (PV), the main antigen is desmoglein 3 (Dsg 3), which is located on t...