Background: Since the number of drug users is increasing, applying a method of detoxification with fewer side effects during withdrawal from opioids and greater reliability seems to be necessary. In addition, without maintenance treatment, there will be limited success of treatment. This study aimed to compare success rates of detoxification with sublingual buprenorphine and clonidine and to ev...

Substance abuse is an important hygienic, psychic and social problem in the world. Gabapentin is a new antiepileptic drug that is used in neurological and psychiatric disorders. Moreover, the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effect on dopamine release due to morphine in animal models have been proved. In the present study, the effect of gab...

Substance abuse is an important health, psychological and social problem in the world. Gabapentin is a new antiepileptic drug. It is used in neurological and psychiatric disorders. Moreover the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effects on dopamine release due to morphine in animal models have been proved. In the present study, the effect of ...

Substance abuse is an important hygienic, psychic and social problem in the world. Gabapentin is a new antiepileptic drug that is used in neurological and psychiatric disorders. Moreover, the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effect on dopamine release due to morphine in animal models have been proved. In the present study, the effect of gab...

BACKGROUND Many drug users present to primary care requesting detoxification from illicit opiates. There are a number of detoxification agents but no recommended drug of choice. The purpose of this study is to compare buprenorphine with dihydrocodeine for detoxification from illicit opiates in primary care. METHODS Open label randomised controlled trial in NHS Primary Care (General Practices)...

Introduction. Relapse rate after opioid detoxification is very high. We studied the possibility that predetoxification patient characteristics might predict relapse at follow-up and thus conducted this 1-year follow-up study to assess the predictors of relapse after inpatient opioid detoxification. Materials and Methods. We conducted this study in our tertiary care institute in India over two-y...

The R2PI-TOF spectra of supersonically expanded rare gas/chiral arene heteroclusters have been rationalized in terms of the distortion of the pi-electron density reflecting the different dipole and quadrupole momenta induced in the rare gas atoms by interaction with the opposite pi-faces of the chiral arene itself.

Reduction of [U(Ts(Tol))(Cl)(μ-Cl)U(Ts(Tol))(THF)2] [2, Ts(Tol) = HC(SiMe2NAr')3; Ar' = 4-MeC6H4)] with KC8 in toluene afforded the new arene-bridged diuranium complex [{U(Ts(Tol))}2(μ-η(6):η(6)-C6H5Me)] (3); combined structural, spectroscopic, magnetic, and computational analyses unambiguously confirm that the uranium centres in 3 are in the +5 oxidation state and the toluene is a 10π-tetraanion.

The objective of this work was to study the effect of mixed culture solid substrate fermentation of C. tropicalis ZD-3 with A. niger ZD-8 on detoxification of cottonseed meal (CSM), and to investigate the effect of fermentation period, proportion of CSM in substrate, sodium carbonate, minerals and heat treatment on the reduction of free gossypol levels during mixed culture solid substrate ferme...