Purpose Progressive retinal ganglion cell (RGC) loss is the pathological hallmark of autosomal dominant optic atrophy (DOA) caused by pathogenic OPA1 mutations. The aim of this study was to conduct an in-depth psychophysical study of the visual losses in DOA and to infer any selective vulnerability of visual pathways subserved by different RGC subtypes. Methods We recruited 25 patients carryi...

1. At its eighth meeting, in decision VIII/19 A.(4), the Conference of the Parties requested the Executive Secretary to complete the assessment on unauthorized harvesting of fauna (including bushmeat) as proposed in document UNEP/CBD/SBSTTA/11/INF/12. Pursuant to this decision, and as a contribution to the in-depth review of the programme of work on forest biodiversity, the Executive Secretary ...

The story of the shopping centre and CBD redevelopment in the regional Queensland city of Ipswich provides a cautionary tale for local politicians and regional civic developers. Indeed, the fact that this history is so bound up in ‘stories’ is a key part of the lessons to be learned. The Ipswich Centre Shopping Plaza was used as a key reference point for the creation of myths shaping a particul...

Convention on Biological Diversity provides for the first time an opportunity to break the nexus widely observed between the biodiversity and the poverty. It is recognized that one could not conserve biodiversity by keeping people poor even if historically biodiversity survived only under such conditions. Studies have shown that many of the communities which conserve diversity have remained poo...

INTRODUCTION The purpose of this study was to measure luminance contrast sensitivity and color vision thresholdfs in normal subjects using a blue light filter lens and transparent intraocular lens material. METHODS Monocular luminance grating contrast sensitivity was measured with Psycho for Windows (version 2.36; Cambridge Research Systems) at 3.0, 6.0, 12.0, 20.0, and 30.0 cycles per degree...

AIM To investigate changes in colour discrimination as a result of chronic hypoxic exposure induced by extreme altitudes (above 8000 m) during an expedition to Mt Everest. METHODS Colour discrimination thresholds for tritan, protan and deutan axes were measured extensively in two male participants (four eyes) during an expedition to Mt Everest, using a quantitative, computer controlled psycho...

Purpose RPE65-associated Leber congenital amaurosis (RPE65-LCA) is a progressive severe retinal dystrophy with early profound dysfunction of rod photoreceptors followed by progressive cone photoreceptor degeneration. We aim to provide detailed information about how cone dysfunction affects color discrimination. Methods Seven adults (aged 16-21) with RPE65-LCA underwent monocular color discrim...

The human histone H3 variant, CENP-A, replaces the conventional histone H3 in centromeric chromatin and, together with centromere-specific DNA-binding factors, directs the assembly of the kinetochore. We purified the prenucelosomal e-CENP-A complex. We found that HJURP, a member of the complex, was required for cell cycle specific targeting of CENP-A to centromeres. HJURP facilitated efficient ...

Rayleigh match data were modeled with the aim of explaining the locations of match midpoints and matching ranges, both in normal trichromats and in subjects with congenital color deficiency. Model parameters included the wavelength of peak sensitivity of cone photopigments, the effective photopigment optical density, and the noise amplitude in the red-green color channel. In order to avoid the ...