dexamethasone induces thymic atrophy and thymocyte apoptosis. in the present study histological and ultrastructural changes which occur in the thymus of the mouse (balb/c) following treatment with high (20 mg/kg) and low (8 mg/kg) doses of dexamethasone were investigated. in low dose treated mice, apoptotic cells were observed focally and localized mainly in thymic nurse cells (t.n.c.). a zone ...

introduction: chemotherapeutic drugs used to treat cancer may cause nausea and emesis by inducing the release of 5-hydroxytryptamine (5-ht) in the small intestine. blockage of 5-ht 3 receptors in the small intestine by 5-ht 3 receptor antagonists might prevent the nausea and vomiting associated with chemotherapy for cancer. the aim of this study was to compare the efficacy and tolerability of t...

Introduction: Febrile seizures are the most common seizure disorder in childhood and its prevalence is estimated to be 2 to 5 percent. There is a relationship between the use of corticosteroids and seizures. This study investigated the effects of dexamethasone pretreatment on convulsive behavior caused by hyperthermia. Methods: In this study, 24 rats aged 19-20 days were divided into 3 group...

introduction: postoperative sore throat is a common complaint in patients with endotracheal intubation and has potentially dangerous complications. this randomized controlled trial study investigated the incidence of postoperative sore throat after general anesthesia when betamethasone gel is applied to a tracheal tube compared with when iv dexamethasone is prescribed.   materials and methods: ...

in this study, the effects of separate and combined intraperitoneal (ip) injections of histidine and dexamethasone were investigated on local inflammation in rats. local inflammation was induced by subcutaneous (sc) injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. the thickness of paw was measured at 30 min before and 30, 60, 90, 120, 150 and 180 min after injection o...

i ntroduction: our study was designed to assess the effect of the submucosal injection of dexamethasone on postoperative discomfort after surgical removal of impacted mandibular third molars. m at erials and methods : twenty six patients with bilaterally bony impacted mandibular third molars were recruited to this split mouth study. on the study side, prior to surgery, 8 mg of dexamethasone was...

oxidative stress is one of the important mechanisms involved in dexamethasone (dex)-induced hypertension. protocatechuic acid (pca) is a natural compound with high antioxidant capacity. in this investigation, the effect of pretreatment with pca was studied in dex-induced hypertensive male wistar rats. for induction of hypertension, dex was injected subcutaneously for 14 days. pca (50, 100 and 2...

Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble ...

Background: Hepatic ischemia/reperfusion injury (I/RI) is a multifactorial pathophysiologic process which can lead to liver damage and dysfunction. This study examined the protective effect of dexamethasone on the gene expression of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) and on the liver tissue damage during warm hepatic I/R. Materials and Methods: A total of 32 mal...