OBJECTIVE The potential of NaHCO3 versus human serum to induce germ tube formation in Candida albicans was investigated. SPECIMENS A total of 100 isolates were obtained from oral swabs of patients presenting with thrush. Approval for the study was granted by the Joint Research Ethics Committee (JREC/23/08). METHOD Confirmed C. albicans isolates by routine methods were tested for germ tube i...

BACKGROUND Laparoscopic cholecystectomy (LC) still leads to significant postoperative nausea and vomiting (PONV) and pain. Our aim was to evaluate the efficacy of dexamethasone or pheniramine hydrogen maleate, either alone or combined, in reducing the stress response and symptoms after LC. METHODS Patients were randomly assigned to 1 of 4 groups, each consisting of 20 patients: control, dexam...

ER maleate [10-(3-Aminopropyl)-3, 4-dimethyl-9(10H)-acridinone maleate] identified in a kinome screen was investigated as a novel anticancer agent for oral squamous cell carcinoma (OSCC). Our aim was to demonstrate its anticancer effects, identify putative molecular targets and determine their clinical relevance and investigate its chemosensitization potential for platinum drugs to aid in OSCC ...

We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget's disease that showed the validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg maintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete response was achieved ...

The effects of perhexiline maleate on growth and drug sensitivity were studied in the P388 murine leukemia cell line and in an anthracycline-resistant subline (P388/ADR). At noninhibitory concentrations, perhexiline maleate markedly increased the sensitivity of P388/ADR cells to doxorubicin but did not have such an effect on anthracycline-sensitive cells. The effects of perhexiline maleate on P...

This study was conducted to know the effectiveness of topical 0.5% timolol maleate for intraocular pressure rise after Nd-YAG laser posterior capsulotomy. Ninety-six eyes 92 patients undergoing capsulotomy were randomly selected pretreatment with maleate, 48 (Group A) or control B). The mean IOP group A 14.8±3.0 mmHg before and 15.7±3.4 (P >0.05), whereas 15.1±3.3 17.2±4.3 <0.05) B. There...

Fluvoxamine maleate is a selective serotonin reuptake inhibitor, which is used for the treatment of different types of depressive disorders. In the present study, a stability indicating HPLC method was developed and validated for the determination of fluvoxamine maleate. The chromatographic separation was carried out using a Nova-Pak CN column and a mixture of K2HPO4 50 mM (pH 7.0) and acetonit...

background: barberry (berberris vulgaris) is a well known medicinal plant in iran and has also been used as food. objective: this study was conducted to evaluate antihistaminic and anticholinergic activity of methanolic extract of barberry fruit. methods: methanolic extract was prepared and pharmacologically studied on isolated guinea- pig ileum, dose- response curves of histamine and acetylcho...

A simple, selective, sensitive and precise, simultaneous high performance liquid chromatographic analysis of syrup containing Chlorphineramine Maleate, Dextromethorphan HBr and Phenylephrin HCl was described. Good chromatographic separation was achieved using a Zorbax C18 (4.6 cm x 250 mm, 5 μm) and a mobile phase consisting of acetonitrile-phosphate buffer pH 3.5 (15:85, v/v) at a flow rate 0....