نتایج جستجو برای: dfpase
تعداد نتایج: 24 فیلتر نتایج به سال:
Over the years our group developed a non-corrosive, non-toxic, environmentally safe and userfriendly chemical agent decontaminant (advanced catalytic enzyme system ACES) in a dry powder form. The ACES is capable of hydrolyzing/detoxifying organophosphorus (OP)-based neurotoxic chemical warfare (CW) agents, i.e. G-type, V-type, and related OP based hazardous industrial materials. Bacterial enzym...
The use of a human protein such as plasma-derived butyrylcholinesterase (huBuChE) to neutralize the toxic effects of nerve agents in vivo has previously been shown to provide both survival in guinea pigs and nonhuman primates and protection against decreased cognitive function in guinea pigs following exposure to a cumulative challenge of 5.5 LD50 of soman. Subsequently, a recombinant form of h...
Human serum paraoxonase-1 (HuPON1) has the capacity to hydrolyze aryl esters, lactones, oxidized phospholipids, and organophosphorus (OP) compounds. HuPON1 and bacterially expressed chimeric recombinant PON1s (G2E6 and G3C9) differ by multiple amino acids, none of which are in the putative enzyme active site. To address the importance of these amino acid differences, the abilities of HuPON1, G2...
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