Java’s RMI (Remote Method Invocation) offers many facilities useful for a distributed application programmer. One of them is distributed garbage collection (DGC) that removes unreachable remote objects. Unfortunately, from the point of view of distributed real-time Java applications, DGC is underspecified (i.e., it may introduce unwanted interference on real-time remote invocations). Some resea...

Dystrophin-glycoprotein complex (DGC) is an important structural unit in skeletal muscle that connects the cytoskeleton (f-actin) of a muscle fiber to the extracellular matrix (ECM). Several muscular dystrophies, such as Duchenne muscular dystrophy, Becker muscular dystrophy, congenital muscular dystrophies (dystroglycanopathies), and limb-girdle muscular dystrophies (sarcoglycanopathies), are ...

Our previous microarray analysis of gastric cancer found that claudin-4 was differentially expressed between intestinal-type gastric cancer (IGC) and diffuse-type gastric cancer (DGC). Claudin-4 is a member of a large family of transmembrane proteins, claudins, essential in the formation and maintenance of tight junctions. To explore the roles of claudin-4 in the two histologically distinct typ...

1 Why Distributed Garbage Collection Dynamically-allocated memory must eventually be reclaimed. But manual reclamation is error-prone, and if an object is de-allocated prematurely, a program that later follows a pointer to it might behave incorrectly. Instead, garbage collection (GC) automatically reclaims objects that can no longer be reached by any path of pointers. In a distributed system, a...

Diffuse-type gastric carcinomas (DGC) exhibit more aggressive progression and poorer prognosis than intestinal-type and other gastric carcinomas. To identify potential therapeutic targets, we examined protein tyrosine phosphorylation in a panel of DGC and other gastric cancer cell lines. Protein tyrosine phosphorylation was significantly enhanced or altered in DGC cell lines compared with that ...

Diffuse-type gastric cancer (DGC) is the most deadly form of gastric cancer and is frequently accompanied by peritoneal dissemination and metastasis. The specific molecular events involved in DGC pathogenesis remain elusive. Accumulating evidence of epigenetic inactivation in tumor suppressor genes led us to conduct a comprehensive screen to identify novel methylated genes in human cancers usin...

Prokaryotes release membrane vesicles (MVs) with direct roles in disease pathogenesis. MVs are heterogeneous when isolated from bacterial cultures so Density Gradient Centrifugation (DGC) is valuable for separation of MV subgroups from contaminating material. Here we report the technical variability and natural biological heterogeneity seen between DGC preparations of MVs for Mycobacterium smeg...

BACKGROUND Numerous clinical trials to improve the success rate of biliary access in difficult biliary cannulation (DBC) during ERCP have been reported. However, standard guidelines or sequential protocol analysis according to different methods are limited in place. We planned to investigate a sequential protocol to facilitate selective biliary access for DBC during ERCP. METHODS This prospec...

objective: selection of sperm for intra-cytoplasmic sperm injection (icsi) is usually considered as the ultimate technique to alleviate male-factor infertility. in routine icsi, selection is based on morphology and viability which does not necessarily preclude the chance injection of dna-damaged or apoptotic sperm into the oocyte. sperm with high negative surface electrical charge, named “zeta ...

The hippocampus is critical for episodic memory and computational studies have predicted specific functions for each hippocampal subregion. Particularly, the dentate gyrus (DG) is hypothesized to perform pattern separation by forming distinct representations of similar inputs. How pattern separation is achieved by the DG remains largely unclear. By examining neuronal activities at a population ...