OBJECTIVE Cooling detection threshold testing may be an important quantitative method for assessing polyneuropathy, in that it has traditionally been viewed as a measure of small-fiber involvement. The present study sought to determine the agreement between two common testing devices and to determine whether these are concordant in their association with predictor variables for diabetic sensory...

In this review, the authors provide evidences that imply the role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of diabetic complications, especially diabetic polyneuropathy. Under chronic hyperglycemia, endogenous TNF-alpha production is accelerated in microvascular and neural tissues, which may undergo an increased microvascular permeability, hypercoagulability, and nerve dam...

Abstract Background Diabetic peripheral neuropathy (DPN) is one of the major diabetic complication and affects quality life (QoL).This study aims at assessing frequency DPN among accidentally diagnosed patients, identifying risk factors linked to in those determine potential effect on QoL. Results According nerve conduction (NCS), 32 patients (44.4%) had polyneuropathy. Polyneuropathy significa...

Diseases of the peripheral nervous system are ranking a leading position among other neurological nosologies. And polyneuropathy is known as more prevalent and severe disease. Numerous scientific reports highlight issues on different pathological conditions in relation to polyneuropathy, particular intoxications, hypovitaminosis (isolated or complications certain processes), infectious heredita...

The increase in the number and life expectancy of patients with diabetes mellitus (DM) worldwide determines high prevalence late complications diabetes, including diabetic polyneuropathy (DPN), most common type polyneuropathy. Oxidative stress is considered main reason for cellular pathology development mellitus, which use antioxidants DPN treatment. Alpha-lipoic acid (ALA), a natural fat-solub...

OBJECTIVE It is controversial whether there is a glycemic threshold above which polyneuropathy develops and which are the most important factors associated with polyneuropathy in the general population. The aim of this study was to determine the prevalence and risk factors of polyneuropathy in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal gl...

The efficacy of treatment with an aldose reductase inhibitor (1,3-dioxo-1 H-benz-de-isoquinoline-2(3H)-acetic acid, AY-22,284, Alrestatin) on peripheral nerve function in diabetic polyneuropathy was assessed. Thirty patients with long-standing diabetes and slight to moderate neuropathy participated in the double-blind placebo trial. Clinical examination, sensory threshold determinations for vib...

Background: Diabetic polyneuropathy is the most common complication in diabetics, occurring 50% of all cases. About 10-20% diabetics are accompanied by neurological pain, showing a tendency to increase with age. Clinical aspects very diverse, from mild abnormalities on nerve conduction tests severe sensory, motor, and autonomic nerves; however, sensory symptoms usually precede motor symptoms. P...