An ideal coronary vasodilator for studying coronary flow reserve in humans would rapidly produce maximal coronary vasodilation, be short acting to permit repeated measurements, and not alter systemic hemodynamics. The two commonly used vasodilators (dipyridamole and meglumine diatrizoate) do not satisfy these criteria; meglumine diatrizoate does not produce maximal hyperemia and dipyridamole ha...

The purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups. The first group was treated with oral zinc sulfate (10 mg/kg/day during 45 days period), and the second group was treated with systemic meglumine antimoniate (20 m...

introduction: myelograghy is a process of instilling contrast medium to the subarachnoid space for evaluating the spinal column by radiography. there are various contrast solutions for different radiographic studies but not all of them are suitable for spinal column evaluation. conclusions: our subject recovered completely without any sequelae after receiving appropriate treatment in a multidis...

OBJECTIVE Pancreatitis is the most common and serious complication of endoscopic retrograde cholangiopancreatography (ERCP). Several studies have compared contrast media (CM) with different osmolalities, but the results are conflicting. We conducted this study to clarify the difference between 2 CM used in ERCP. METHODS Five hundred and seventy-six patients were examined by using ERCP in our ...

The crystal structure of meglumine diatrizoate has been solved and refined using synchrotron X-ray powder diffraction data optimized density functional theory techniques. Meglumine crystallizes in space group P2 1 (#4) with a = 10.74697(4), b 6.49364(2), c 18.52774(7) Å, β 90.2263(3), V 1292.985(5) Å 3 , Z 2. Two different structures, which yielded essentially identical refinement residuals pos...

The present study was conducted to compare the imaging quality of non-ionic (iohexol) and ionic (sodium meglumine diatrizoate) contrast agents for intravenous urography in dogs. Twelve clinically healthy adult dogs were randomly divided into two groups I II, consisting six either sex each. Two relevant radiographic exposures i.e. ventro-dorsal right lateral views obtained survey following evalu...

Early angiography after cerebral arterial occlusion has been cited as potentially detrimental. This investigation evaluates the effect of acute angiographic contrast medium administration on the cortical edema induced by middle cerebral artery (MCA) occlusion. Sixteen rats underwent MCA occlusion, and after 1 hour half the rats underwent ipsilateral internal carotid injection of meglumine diatr...

The effect of an intravenous bolus of 4.3 ml/kg of 60% meglumine diatrizoate on the blood-brain barrier (BBB) was studied in five adult unanesthetized dogs. Intravenous 3% Evans blue dye (4 ml/kg) was used as an indicator of BBB disruption. The animals were observed for signs of neurotoxicity for 1 hr after contrast-medium injection and then sacrificed. Their brains were removed and sectioned. ...

High doses of diatrizoate meglumine-60 were administered intravenously in varying concentrations to determine what effect they might have on the blood-brain barrier. In dogs, doses of 4 ml / kg and above appeared to disrupt parts of the blood-brain barrier, disruption being manifested on computed tomographic scans as enhancement and on corresponding brain sections as Evans blue stains. Disrupti...