In the title compound, C(14)H(16)BrNO(4), inter-molecular C-H⋯O hydrogen bonds link the mol-ecules, forming a stable structure. An intra-molecular N-H⋯O hydrogen bond results in the formation of a six-membered ring and helps to establish the mol-ecular conformation which is almost planar, with an r.m.s deviation of 0.0842 Å.

The cycloalkylation of diethyl malonate and ethyl cyanoacetate with alkyl dihalide was investigated by using comminuted potassium carbonate as a base and toluene as a solvent in the presence of hexadecyltrimethylammonium bromide (HTMAB) as a phase-transfer catalyst, which provided a conventional procedure with the advantage of short reaction period and high product yield. The factors influencin...

A photocatalytic process for selective arylalkylation of allylic alcohols with α-bromo diethyl malonate has been developed. The reaction provided a straightforward approach to synthesize α-aryl-β-alkylated ketones via unique 1,2-aryl migration. The procedure is highlighted by its operational simplicity and mild reaction conditions.

Chalcones are still challenge substrates in Michael reactions, and only limited success has been achieved. This work describes a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.

The insertion of a -NO2 group onto the corrole framework represents a key step for subsequent synthetic manipulation of the macrocycle based on the chemical versatility of such a functionality. Here we report results of the investigation of a copper 3-NO2-triarylcorrolate in nucleophilic aromatic substitution reactions with "active" methylene carbanions, namely diethyl malonate and diethyl 2-ch...

ÐKnoevenagel condensation between 3-nitro-2-pyridinecarbaldehyde and diethyl malonate catalyzed by titanium(IV) chloride gave diethyl 3-nitro-2-pyridylidenemalonate which was oxidized with peracetic acid to give corresponding 1-oxide. Reaction of the latter with diethylamine in the presence of primary and secondary alcohols resulted in the reduction of the nitro group and the oxidation of the v...