General information...........................................................................................S2 General procedure..............................................................................................S3 Detailed descriptions for products..........................................................................S4 Identification of by-product of diethyl (1-phenylvinyl) pho...

OBJECTIVE Prenatal exposure to organophosphate pesticides can lead to developmental neurotoxicity. A longitudinal birth cohort was established to investigate pesticide exposures from different agricultural activities. Maternal urinary organophosphate metabolites were measured at 28 weeks of pregnancy (n=86), delivery (n=67) and 2 months postpartum (n=51). METHOD Subjects were interviewed with...

Correction for 'Reaction mechanisms in ionic liquids: the kinetics and mechanism of the reaction of O,O-diethyl (2,4-dinitrophenyl) phosphate triester with secondary alicyclic amines' by Paulina Pavez et al., Org. Biomol. Chem., 2016, DOI: 10.1039/c5ob02128f.

Phosphotriesterase (PTE) from Pseudomonas diminuta is a zinc metalloenzyme that hydrolyzes a variety of organophosphorus compounds. The kinetic parameters of Zn/Zn PTE, Cd/Cd PTE, and a mixed-metal Zn/Cd hybrid PTE were obtained with a variety of substrates to determine the role of each metal ion in binding and catalysis. pH-rate profiles for the hydrolysis of diethyl p-nitrophenyl phosphate (I...

background: phthalates are a group of multifunctional chemicals. diethyl phthalate (dep) is one of the most frequently used phthalates in solvents and fixatives for numerous industrial products. method: the present experiment was designed to assess oxidative stress, if any, caused by diethyl phthalate. for this the homogenates of liver and kidney were treated with different concentrations ( 10-...

the colon, adenocarcinoma of the breast) and on nonneoplastic tissues from cancer patients (liver, kidney, spleen, brain, and red blood cells). Eighteen distinct nonspecific esterase bands have been identified and characterized with respect to substrate preference and inhibitor profile. Each of the normal tissues contains a readily recognizable esterase pattern; the tumor extracts present great...

20 min after intraportal infusion of diethyl phosphate (DEP) in rats, the mitochondrial cardiolipin (CL; 1,3-bisphosphatidyl glycerol) fraction is labelled with DEP. The obtained mixture of CL and DEP-labelled CL, which up to now has not been separated, behaves chromatographically (fractogel; HPLC: TLC), in respect to release of DEP and also in respect of the 31P NMR spectrum as a mixture of CL...

The pH rate profile for the hydrolysis of diethyl-p-nitrophenyl phosphate catalyzed by the phosphotriesterase from Pseudomonas diminuta shows a requirement for the deprotonation of an ionizable group for full catalytic activity. This functional group has an apparent pKa of 6.1 +/- 0.1 at 25 degrees C, delta Hion of 7.9 kcal/mol, and delta Sion of -1.4 cal/K.mol. The enzyme is not inactivated in...

A birth cohort was begun to investigate the levels and sources of pesticide exposure in pregnant women living in Thailand, and to examine the effects of pesticide exposure on infant neurodevelopment at five months of age. Subjects were interviewed using questionnaires regarding their demographic characteristics, educational background, and work and home activities related to pesticide exposures...