Although NO donors have been shown to confer late preconditioning (PC) against myocardial ischemia/reperfusion injury in healthy rabbits, it is unknown whether concurrent systemic disorders affect NO donor-induced cardioprotection. Since many patients with coronary artery disease have hypercholesterolemia (HC), we examined the effect of this condition on late PC induced by the NO donor diethyle...

Although ischemia-induced late preconditioning (PC) is known to be mediated by inducible nitric oxide (NO) synthase (iNOS), the role of this enzyme in pharmacologically induced late PC remains unclear. We tested whether targeted disruption of the iNOS gene abrogates late PC elicited by three structurally different NO donors [diethylenetriamine/NO (DETA/NO), nitroglycerin (NTG), and S-nitroso-N-...

Two-dimensional inorganic nanomaterials have drawnmuch attention due to their excellent properties and wide applications associated with unique 2D structures. However, an efficient and versatile chemical synthesis method using ambient conditions for 2D nanomaterials, especially with secondary structures (e.g. mesopores), has still not been reported. Herein, we report a versatile method to synth...

Resistive breathing (encountered in chronic obstructive pulmonary disease and asthma) results in cytokine upregulation and decreased nitric oxide (NO) levels in the strenuously contracting diaphragm. NO can regulate gene expression. We hypothesized that endogenously produced NO downregulates cytokine production triggered by strenuous diaphragmatic contraction. Wistar rats treated with vehicle, ...

Utilising self-assembled monolayers (SAMs) to achieve area-selective atomic layer deposition (AS-ALD) as an approach bottom-up nanofabrication has recently gained significant attention from the nanoelectronics industry. With continued downscaling of feature sizes, top-down processing can no longer reach challenging demands industry which requires conformal coating high aspect ratio vias and a r...

An easy, effective and eco-friendly one-pot process for the preparation of 4H-pyran compounds has been established by using a catalytic amount reduced graphene oxide functionalized with diethylenetriamine (rGO-DETA) in water under mild conditions. The catalyst was very this reaction provided desired products 1a–t good to high yields (87%–97%) short times. Moreover, rGO-DETA composite could be r...

Changes in macromolecular mobility during the thermal oxidation of epoxy-amine thermoset networks are addressed this study. Three systems, cured with DGEBA and three similar aliphatic hardeners – ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA) aged at 160°C characterized by dynamic mechanical analysis (DMA). Results show a split single initial α relaxation peak agi...

In the present work, a specific three-point bending test is applied to evaluate how roughness can impact bond strength (adherence) and mechanism of interfacial failure initiation. The study conducted using an aluminum alloy 2024-T3 as substrate DGEBA (polyepoxide bisphenol A diglycidyl ether) /DETA (diethylenetriamine) adhesive, considering different abrasive surface treatments. An optimal reac...

Mitochondrial permeability transition (MPT) pores have recently been implicated as a potential mediator of myocardial ischemic injury. Nitric oxide (NO) donors induce a powerful late phase of cardioprotection against ischemia-reperfusion injury; however, the cellular mechanisms involved are poorly understood. The role of MPT pores as a target of cardioprotective signaling pathways activated by ...