buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. a mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.in this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a strong base, t-BuXPhos is employed as the supporting ligand; at 110 °C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and rece...

Rotational spectra have been measured for six isotopomers of the dimethylamine dimer using a Fourier-transform microwave spectrometer. No tunneling splittings were observed for either the aor c-type rotational transitions and the spectra could be fit to a rigid rotor Hamiltonian including centrifugal distortion terms. Possible dimer structures are discussed and compared to the experimentally de...

--The extent of formation of N-nitrosodimethylaminc {NDMA) in the stomachs of rats and mice after sirnultancous oral administration of [ C]dimethylamine and potassiu.m nitrite ~as determined by measuring the methylation of liver DNA. With doses of around I mg d1m~thylamm~ hydrochloride/kg body weight and 50 mg potassium nitrite/kg body w~ight. OJ{'\, of the arnme was n:.tr~satcd . on average. T...

The trimethylamine content of most marine fish, especially the gadoid species, is internationally accepted as an index ofspoilage. However, ammonia, dimethylamine, and other aminesalso contribute to the trimethylamine value. Variations in the conditions of the three current methods used to analyze for trimethylamine content were studied in detail to determine the best condition to extract trime...