OBJECTIVE To compare oral misoprostol solution with vaginal prostaglandin gel (dinoprostone) for induction of labour at term to determine whether misoprostol is superior. DESIGN Randomised double blind placebo controlled trial. SETTING Maternity departments in three hospitals in Australia. Population Pregnant women with a singleton cephalic presentation at > or = 36+6 weeks' gestation, with...

Objectives To investigate the efficacy and safety of misoprostol in the induction of labor at term by comparing this agent with the commonly used dinoprostone gel. Patients and methods A randomized clinical trial of vaginal misoprostol, 50 μg 6-hourly, and dinoprostone gel, 1–2 mg 6-hourly, in 435 women undergoing induction of labor at term. The women, 210 in the misoprostol group and 225 in th...

BACKGROUND The objective of this randomized prospective study was to compare the efficacy of 50 mcg vaginal misoprostol and 3 mg dinoprostone, administered every nine hours for a maximum of three doses, for elective induction of labor in a specific cohort of nulliparous women with an unfavorable cervix and more than 40 weeks of gestation. MATERIAL AND METHODS One hundred and sixty-three pregn...

OBJECTIVES To compare the efficacy of 25 vs. 50 microg of intravaginal misoprostol vs. intracervical dinoprostone for cervical ripening and labor induction. MATERIALS AND METHODS 210 women with Bishop's score <6 were randomized into 3 groups of 70 each to receive 6 hourly doses of either 25 or 50 microg of intravaginal misoprostol or 0.5 mg intracervical dinoprostone to maximum of 3 doses and...

BACKGROUND We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score ≤ 5. METHODS This was a prospective case-control study, which included 104 consecutive women with a Bishop score≤5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score≤5 underwe...

432 The off-label use of drugs is common, particularly in paediatrics, where many drugs have yet to undergo the rigorous scrutiny demanded by authorities such as the Medicines Control Council (MCC) and the US Food and Drug Administration (FDA) before registration. 1,2 Yet some drugs (e.g. paracetamol, salbutamol) are so commonplace in paediatric practice that it may come as a surprise that thei...

Objective: The aim of this study was to investigate the effect of parity on cervical ripening and labor induction with intra-vaginal slow-release dinoprostone and to determine the safety and efficacy of this medication in a tertiary referral center. Methods: The medical records of 2090 pregnant women who underwent cervical ripening and induction of labor with Dinoprostone between January 2007 a...

The goal of obstetrics is a pregnancy that culminates in a healthy infant and a minimally traumatized mother. Ideally all pregnancies should go to term and labour should begin spontaneously. More often than not, the need for delivery is clear but the timing is not emergent and the route is not dictated by foetal demands. A method to initiate the normal process of labour at a time before labour ...

Induction of labour is a common need in obstetrics ward. There are various complications and drug side effects associated with it. This study has been designed to compare the safety and efficacy of 50μg intra-vaginal misoprostol (PGE1 analogue)with 0.5mg intracervical dinoprostone gel (PGE2). . 40 pregnant women with different indications of induction of labour participated in the study. They w...

OBJECTIVE To compare the efficacy and safety of two prostaglandin derivatives, misoprostol and dinoprostone, for ripening the cervix and inducing labor in women with an unfavorable cervix. METHODS One hundred fifty-five women admitted for induction of labor to St. John's Mercy Medical Center, a teaching community hospital, were randomized to one of two methods: intravaginal misoprostol, 50 mi...