BACKGROUND/AIM Treadmill test combined with myocardial perfusion scintigraphy (MPS) is a commonly used technique in the assessment of coronary artery disease. There are many patients, however, who may not be able to undergo treadmill test. Such patients would benefit from pharmacological stress procedures combined with MPS. The most commonly used pharmacological agents for cardiac stress are co...

The antineoplastic efficacy of P-4055, a 5'-elaidic acid (C18:1, unsaturated fatty acid) ester of cytarabine, a nucleoside antimetabolite frequently used in the treatment of hematological malignancies, was examined in several in vivo models for human cancer. In initial dose-finding studies in nude mice, the efficacy of P-4055 was highest when using schedules with repeated daily doses. In a Raji...

Increased levels of systemic vascular endothelial growth factors (VEGFs) in patients with diabetes are associated with increased risk of microvessel disease. On the other hand, low VEGF levels after intravitreal antibody application may be associated with acute cardiovascular complications and treatment failure. Individual levels of systemic VEGF vary in a wide range depending on analytical met...

The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...

There are several reports that a protein-free extract of heart muscles from mamma lian animals dilates coronary vessels (1, 2), increases the amplitude of heart (3), and im proves the efficiency of contractions in heart lung preparations (4). Clinically, the extract has been used as an antianginal drug (5, 6), and a drug for heart failure contradictorily (7, 8). One of the main approaches to an...

OBJECTIVES Residents of nursing homes often have difficulty swallowing (dysphagia), which complicates the administration of solid oral dosage formulations. Erroneously crushing medication is common, but few interventions have been tested to improve medication safety. Therefore, we evaluated the effect of warning symbols in combination with education on the frequency of erroneously crushing medi...

The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...

the bioavailability of two dipyridamol tablet formulations of (dipyridamole from tolidaru and persantin from boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (t) and the reference (r) products in a randomized balanced 2-way crossover design. plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by hplc ...

positive defects are mainly observed in the inferoposterior, inferior, and apical myocardium, which could be explained by differences in regional blood flow during ventricular pacing [4] . Importantly, these perfusion abnor malities are more prominent during physical exercise compared with pharmacological stress using dipyridamole or adenosine [5] . Stress echocardiography is usually performed ...

This eighty-year-old gentleman presented to accident and emergency with right arm weakness. The patient reported a sudden onset of right neck pain at rest radiating to his right shoulder and back, leading to immediate numbness and tingling down his right arm and associated heaviness. There was no report of any preceding trauma or headache. He had a past history of hypertension, tablet controlle...