Background/Aims The inflammatory bowel disease disability index (IBD-DI) was recently developed for IBD to assess the functional consequences and disease burden. We applied the IBD-DI to a Korean population and identified predictive factors influencing IBD-related disability. Methods Between March and August 2015, 322 consecutive patients with IBD were prospectively recruited. Patients comple...

At percent, Zn stress tolerance using novel genetic resources is an important mitigation strategy for plant breeding. In this study, thirty-five durum wheat genotypes with different growth habits were evaluated under normal (non-stress) and Zn deficient stress during the 2014-15 cropping season. A total of ten Zn stress tolerance indices including stress tolerance index (STI), relative zinc-def...

in this paper, we study rst order linear fuzzy dierential equations with fuzzy coecient and initial value. we use the generalized dierentiability concept and apply the exponent matrix to present the general form of their solutions. finally, one example is given to illustrate our results.

dae and pdae are systems of ordinary and partial di erential-algebraic equations with constraints. They occur frequently in applications such as constrained multibody mechanics, space-craft control and incompressible uid dynamics. A dae has di erential index r if a minimum of r+1 di erentiations of it are required before no new constraints are obtained. While dae of low di erential index (0 or ...

OBJECTIVE To evaluate the long-term effectiveness and safety of 10 years of adalimumab (ADA) treatment in DMARD-refractory RA patients and to analyse efficacy based on RF status and baseline disease duration. METHODS DE020 was a multicentre, phase 3, open-label continuation study. Adult RA patients who received s.c. ADA (40 mg every other week or monthly) in one of four early assessment studi...

objective: peripheral arterial disease (pad) is a state characterized by atherosclerotic occlusive disease of lower extremities. diabetes is the main risk factor for pad. material and methods: to assess the prevalence of pad, a cross sectional study was performed on 352 diabetic patients who referred to yazd diabetes research center from 2007 to 2010. vascular assessment was done by measuring t...

OBJECTIVE To examine associations between serum macrophage migration inhibitory factor (MIF) and disease-related variables and corticosteroid use in patients with systemic lupus erythematosus (SLE). METHODS Serum MIF concentration was measured by ELISA in 90 female patients with SLE and 279 healthy controls. Univariate and multivariate regression analyses were used to examine the associations...

Method 87 pts. (f 69%, m 31%) average age 14,1 yrs. disease duration 5,2 yrs., were follow up for 3,7 (2-5) yrs. Parents/ patients over 12 yrs. completed CHAQ at the beginning and at the end of study and disability index (DI) was calculated. CHAQ DI=0 was considered as normal, 0,1250,5=mild, ≥0,6=moderate/severe disability. Fifty nine (67,8%)pts. were treated with methotrexate, 42 (52,8%)pts. w...

np-c is a severe, progressive and irreversible neurovisceral disease, which is invariably fatal. np-c is a rare disease, with an estimated minimal incidence of 1/120,000 live births . np-c is caused by mutations in npc1 (~95% of patients) or npc2 genes .defective npc1 and npc2 proteins result in a disruption of lipid metabolism . one of special features of this disorder is heterogeneous manifes...

OBJECTIVE To compare the relationship between clinical measures and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with tofacitinib or methotrexate (MTX). METHODS In a phase 3 randomised controlled trial, patients (N=956) who were MTX-naïve or had received ≤3 doses were randomised and received tofacitinib 5 or 10 mg twice daily or MTX titrated to 20 mg/wee...