The present study investigated the anticonvulsive effect of the disubstituted diaryl diselenides diphenyl diselenide (PhSe)(2), m-trifluoromethyl-diphenyl diselenide (m-CF(3)-C(6)H(4)Se)(2), p-chloro-diphenyl diselenide (p-Cl-C(6)H(4)Se)(2) and p-methoxyl-diphenyl diselenide (p-CH(3)O-C(6)H(4)Se)(2) on a chemical model of seizure induced by pentylenetetrazole (PTZ) in mice. (PhSe)(2), (p-Cl-C(6...

This study was designed to investigate the protective effects of the combination of guanosine and 2 organoselenium compounds (ebselen and diphenyl diselenide) against glutamate-induced oxidative stress in different regions of rat brains. Glutamate caused an increase in reactive oxygen species (ROS) generation and a decrease in [(3)H]-glutamate uptake in striatal, cortical, and hippocampal slice...

Three components, one pot synthesis of thiasalen/selenasalen Ni(II), Pd(II) and Pt(II) complexes, 14-19, by the oxidative addition of S-S/Se-Se bond of bis(o-formylphenyl)disulfide/-diselenide to Ni(0), Pd(0) and Pt(0) followed by in situ Schiff base formation with ethylenediamine is reported. S-S or Se-Se bonds were cleaved and coordinated to the metal center as thiolate (ArS(-)) or selenolate...

Anuroctoxin (AnTx), a 35-amino-acid scorpion toxin containing four disulfide bridges, is a high affinity blocker of the voltage-gated potassium channel Kv1.3, but also blocks Kv1.2. To improve potential therapeutic use of the toxin, we have designed a double substituted analog, [N17A/F32T]-AnTx, which showed comparable Kv1.3 affinity to the wild-type peptide, but also a 2500-fold increase in th...

Diselenide exchange is introduced as a reversible reaction in dynamic combinatorial chemistry in water. At neutral pH, diselenides are found to mix with disulfides and form dynamic combinatorial libraries of diselenides, disulfides, and selenenylsulfides.

A brief survey is given of the thermochemistry of a number of silicon-containing substances that are of interest in modern technology. Among those discussed are: silicalite (SiO2), silicon disulfide (SiS2), the crystalline and vitreous forms of silicon diselenide (SiSen), silicon sesquitelluride (Si2Te3), silicon nitride (Si3N4), and vanadium disilicide (VSi2).

The reaction of 2,4-bis(phenyl)-1,3-diselenadiphosphetane-2,4-diselenide (Woollins' Reagent, WR) with phenylalkylcyanamides (RR'NC[triple bond, length as m-dash]N, R = PhCH2CH2, R' = CH3 and R = PhCH2CH2CH2, R' = H) in refluxing toluene led to novel heterocyclic selenazadiphospholaminediselenides and (43% and 42% yields), the latter being hydrolyzed to the unusual zwitterionic carbamidoyl(pheny...

With the massive consumption of fossil fuels and its detrimental impact on the environment, methods of generating clean power are urgent. Hydrogen is an ideal carrier for renewable energy; however, hydrogen generation is inefficient because of the lack of robust catalysts that are substantially cheaper than platinum. Therefore, robust and durable earth-abundant and cost-effective catalysts are ...

The ephedrine-based diselenide appears as a new promiscuous catalyst, able to generate optically active alcohols by addition of organozinc to aldehydes (up to 97% ee), and shows powerful GPx like activity, reducing H(2)O(2) to water in only 16.33 min (eleven times faster than PhSeSePh).