Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant with a slightly bitter taste having short half-life of 2.5 h. In the present study effect of co-processed excipient bases in formulation of orodispersible tizanidine HCl tablets by direct compression method was investigated. Co-processed excipient of microcrystalline cellulose with SSL-hydroxypropylcellulose was prepare...

   Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...

New era is an era of novel drug delivery systems. Pediatric, Geriatric and bed ridden patients have difficulties in swallowing tablets. The purpose of the present study was to develop and characterize mouth dissolving tablets of Levocetrizine Hydrochloride by using direct compression technique. Formulations were designed by factorial design technique. Sodium starch glycolate, Crospovidone and C...

The polyherbal decoction, Gulugulutitakam is known for the treatment of various inflammatory conditions. For the ease of administration, this dosage form has been converted into tablets containing high amount of dry extract but it has the disadvantage of longer disintegration and dissolution parameters. In our attempt to develop tablets with improved disintegration and dissolution time, we have...

RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. Marketed freeze dried tablet of RZT is available. Freeze drying is cumbersome and it yields a ...

This study was aimed at evaluating chitosan-microcrystalline cellulose blends as direct compression excipients. Crab shell chitosan, α-lactose monohydrate, and microcrystalline cellulose powders were characterized. Blends of the microcrystalline cellulose and chitosan in ratios 9 : 1, 4 : 1, 2 : 1, and 1 : 1 as direct compression excipients were made to constitute 60% of metronidazole tablets. ...

This study used chicken manure classified as lignocellulosic biomass due to its high straw content. paper compares the possibility of using pulsed electric field (PEF) pretreatment substrates with ultrasonic disintegration (UP) increase methane production. As for treatment, BMP increased from 210.42 ± 7.92 mL/g VS 250.06 8.68 VS, whereas PEF disintegration, ratio 248.90 9.29 VS. The use and UP ...

PURPOSE The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant. METHODS Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of th...