STUDY OBJECTIVES The degree to which physical exercise habits are related to sleep-disordered breathing is not known. We sought to investigate the association between a single-item exercise question and laboratory-assessed sleep-disordered breathing. DESIGN A population-based cross-sectional epidemiologic study of adults measured the association between exercise and sleep-disordered breathing...

Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-living individuals who underwent overnight, unattended polysomnography at home....

OBJECTIVE Sleep disordered breathing with central apnea or hypopnea frequently occurs at high altitude and is thought to be caused by a decrease in blood CO(2) level. The aim of this study was to assess the effects of added respiratory dead space on sleep disordered breathing. METHODS Full polysomnographies were performed on 12 unacclimatized swiss mountaineers (11 males, 1 female, mean age 3...

Sleep-related breathing disorders are strongly associated with increased risk of stroke independent of known risk factors. The direction of causation favors sleep-disordered breathing leading to stroke rather than the other way around, although definitive proof of this awaits the results of prospective cohort studies. If causal, even a moderately elevated risk of stroke coupled with the high pr...

Caples, Sean M., Robert Wolk, and Virend K. Somers. Influence of cardiac function and failure on sleep-disordered breathing: evidence for a causative role. J Appl Physiol 99: 2433-2439, 2005; doi:10.1152/japplphysiol.00676.2005.— Heart failure is an increasingly common public health problem that is strongly linked to both central and obstructive sleep apnea, collectively referred to as sleep-di...

Questions remain as to whether pediatric sleep disordered breathing increases the risk for elevated blood pressure and blood pressure-dependent cardiac remodeling. We tested the hypothesis that activity-adjusted morning blood pressure surge, blood pressure load, and diurnal and nocturnal blood pressure are significantly higher in children with sleep disordered breathing than in healthy controls...

Wakefulness, NREM sleep, and REM sleep are accompanied by specific changes in breathing control, which arise from the interaction of automatic (metabolic, involuntary) and behavioural (voluntary and involuntary control systems. Considering the complexity in the neuroanatomy and neurophysiology of breathing control, it is not surprising that neurologic disorders are frequently accompanied by sle...

Sleep is a fundamental physiological process necessary for recovery from acute illness. Unfortunately for hospitalized patients, sleep is often short, fragmented, and poor in quality, and may be associated with adverse outcomes including inpatient delirium. Many factors contribute to poor sleep in the hospital setting, including preexisting sleep deprivation, sleep disordered breathing, environ...

Measurements and main results: Relative to subjects with a respiratory disturbance index of less than 5.0 events/hour (the reference category), subjects with mild SDB (5.0–14.9 events/hour) and moderate to severe SDB (≥15 events/hour) had adjusted odds ratios of 1.27 (95% confidence interval: 0.98, 1.64) and 1.46 (95% confidence interval: 1.09, 1.97), respectively, for fasting glucose intoleran...

A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Assessment of upper airway dynamics in awake sleep apnea patients wi...