In a previous paper, Brouwers and Van Eijk [1] presented a theoretical study on the dissolution (reaction) of pulverised powder coal fly ash. This fly ash was modelled as hollow spheres, and a shrinking core model was derived for these hollow spheres that contain two regions (an outer hull and an inner region). The obtained analytical equations were applied to the dissolution experiments by Pie...

Meloxicam is widely prescribed as an analgesic and anti-inflammatory drug in human therapeutics. Owing the very low aqueous solubility of meloxicam, this property has been studied dimethyl sulfoxide (DMSO)-aqueous solvent systems at several temperatures from 273.15 to 313.15 K expand database about drugs mixed solvents. The flask shake method followed by ultraviolet-visible (UV-vis) spectrophot...

The heat of vaporization of a pure substance at its normal boiling temperature is a very important property in many chemical processes. In this work, a new empirical method was developed to predict vaporization enthalpy of pure substances. This equation is a function of normal boiling temperature, critical temperature, and critical pressure. The presented model is simple to use and provides an ...

Hildebrand and Hansen solubility parameters are commonly used to identify suitable solvents for the dispersion or dissolution of a range of solutes, from small molecules to graphene. This practice is based on a number of equations which predict the enthalpy of mixing to be minimized when the solubility parameters of solvent and solute match. However, such equations have only been rigorously der...

Regardless of the administration route, the key factor for the success and reliability of any formulation is drug bioavailability, defined as the rate and extent at which the active drug is absorbed from a pharmaceutical form and becomes available at the site of drug action.1 Although metabolism and physiological factors highly affect drug absorption by living tissues, bioavailability is strong...

The activity of thermo-transient receptor potential (TRP) channels is highly dependent on temperature, and thus thermo-TRP reactions have a high temperature coefficient Q 10. In thermodynamics, a high value of Q 10 indicates the existence of a large activation energy (i.e., a large enthalpy) over a short period during the transition process between the closed and open states of the channels. Th...

Results: A total of 247 plastic surgeons were included. 78.6% cited previous work at least once (mean 34.3 +/87.5 self-citations). These self-citations accounted for 4.8% of all citations. Including self-citations in bibliometric analyses increased h-indices from 9.5 +/6.9 to 10.2 +/7.6. A minority of researchers (20.1%) increased their h-index via self-citation by at least one integer value (r...

ABSTARCT:Emulsion Solovent Diffusion (EDS) technique combines crystallization and agglomeration directly to generate spherical agglomerates with improved micromeretic properties, thus obviating need for further processing by granulation and agglomeration. The present study was focused on spherical crystallization of an antifungal drug Gresiofulvine (GRV) using above mentioned ESD technique in w...

Artemisinin (ARMN) is a potent antimalarial drug, which is effective against multidrug resistant strains of Plasmodium falciparum and produces rapid recovery even in patients with cerebral malaria. Being poorly soluble in water, artemisinin is incompletely absorbed after oral intake due to poor dissolution characteristics in the intestinal fluids. To enhance these properties, solid dispersions ...