Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.

Cells in the Drosophila wing are polarised to produce a single distally pointing trichome. Recent studies show that this requires the recruitment of the Dishevelled protein to the distal cell edge, and the correct levels of Rho-associated kinase activity.

background: an intra-articular distal humerus mal:union: can be disabling. to improve function, reduce pain and/ or prevent further secondary osteoarthritis an intra-articular corrective osteotomy can be considered. herein we present the indications, practical guidelines for pre- operative planning and surgical technique. subsequently, we provide long-term results in a small series.   methods: ...

Longitudinal stent deformation (LSD) is a rare complication but can occur during coronary intervention. We report a case with LSD of the distal edge, documented by an optical coherence tomography investigation and successfully recovered.

The effect of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton beams. Treatment with ECyd significantly enhanced the proton-induced loss of clonogenicity and incre...

A 63-year-old male was admitted with subacute anterior ST-elevation myocardial infarction. Cardiac catheterization revealed a subtotal occlusion in the proximal and middle part of left anterior descending coronary artery. Subacute stent thrombosis (SAT) occurred recurrently until the last stent deployment solved the problem of the uncovered artery and distal-stent edge dissection. The patient's...

INTRODUCTION AND OBJECTIVES At present, the effect of paclitaxel on tissue structure at the edges of Taxus(R) stents is unknown. The objective of this study was to investigate in vivo the temporal changes occurring at the edges of paclitaxel-eluting stents using intravascular ultrasound radiofrequency (IVUS-RF) data analysis. METHODS The study included 24 patients who had a total of 26 paclit...

CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the ends of growing microtubules and may act as anti-catastrophe factors. Here, we have isolated two CLIP-associated proteins (CLASPs), which are homologous to the Drosophila Orbit/Mast microtubule-associated protein. CLASPs bind CLIPs and microtubules, colocalize with the CLIPs at microtubule distal ends, an...

introduction: distal radius fractures are a common traumatic injury, particularly in the elderly population. in the present study we examined the effectiveness of ultrasound guidance in the reduction of distal radius fractures in adult patients presenting to emergency department (ed). methods: in this prospective case control study, eligible patients were adults older than 18 years who presente...

At the gastroesophageal junction, most vertebrates possess a functional lower esophageal sphincter (LES) which may serve to regulate the passage of liquids and food into the stomach and prevent the reflux of gastric contents into the esophagus. Snakes seemingly lack an LES and consume meals large enough to extend anteriorly from the stomach into the esophagus thereby providing the opportunity f...