Amphetamine-type psychostimulants (ATS) are used worldwide by millions of patients for several psychiatric disorders. Amphetamine (AMPH) and "ecstasy" (3,4-methylenedioxymethamphetamine or MDMA) are common drugs of abuse. The impact of chronic ATS exposure to neurons and brain aging is still undisclosed. Current neuronal culture paradigms are designed to access acute ATS toxicity. We report for...

The planktonic freshwater crustacean of the genus Daphnia are a model system for biomedical research and, in particular, invertebrate-parasite interactions. Up until now, no virus has been characterized for this system. Here we report the discovery of an iridovirus as the causative agent of White Fat Cell Disease (WFCD) in Daphnia WFCD is a highly virulent disease of Daphnia that can easily be ...

We previously reported that two trifluoromethyl ketones, 3,3,3-trifluoro-1-phenyl-1,2-propanedione (TF1) and 1,1,1-trifluoro-3-phenyl-2-propanone (TF2), have neuroprotective effects against low K(+)-induced apoptosis in cerebellar granule neurons (CGNs) exposed at 12-13 days in vitro (DIV). On the other hand, these compounds showed weak neuroprotective potency against 7 DIV CGNs. It is reported...

OBJECTIVE To evaluate and compare the depth of curve of Spee in class I, class II div 1 class II div 2, class II subdivision and class III malocclusion. METHODS A Cross sectional study was done at Dr Irshat-UI-Ebad Khan Institute of Oral Health Sciences, Karachi, Pakistan (DIKIOHS) from Oct 2009 to March 2010. The sample of 100 adolescent patients selected according to the inclusion criteria ...

PODCAST INTERVIEW with:Rachel LegmannDirector of Technology, Gene Therapy Rachel has more than 25 years experi...

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><div class="column"><p>Como consecuencia de la irrupción un evento tan crítico como Covid-19, las ciencias sociales y humanas han comenzado a repensar los conceptos e ideas que establecían complejidad del mundo en habitamos. Por ejemplo, reflexionando sobre el “pensar global”, expresión ac...

Because the Developmental Neurotoxicity Testing Guidelines require large numbers of animals and is expensive, development of in vitro approaches to screen chemicals for potential developmental neurotoxicity is a high priority. Many proposed approaches for screening are biochemical or morphological, and do not assess function of neuronal networks. In this study, microelectrode arrays (MEAs) were...