Dishevelleds are modular proteins that lie at the crossroads of divergent Wnt signaling pathways. The DIX domain of dishevelleds modulates a beta-catenin destruction complex, and thereby mediates cell fate decisions through differential activation of Tcf transcription factors. The DEP domain of dishevelleds mediates planar polarity of cells within a sheet through regulation of actin modulators....

Introduction Benign Paroxysmal Positional Vertigo is the most common cause of dizziness in elderly people. Recent studies have shown that the elderly present higher Benign Paroxysmal Positional Vertigo recurrence and that vertiginous symptomatology remission varies according to comorbidities and the therapeutic techniques applied. Objective To assess the short-term effectiveness of Vestibular R...

We address the problem of time to depth conversion of time migrated seismic images and show that the Dix velocities estimated from time migration velocities are the true seismic velocities divided by the geometrical spreading of image rays. We pose an inverse problem: to find seismic velocities from Dix velocities and suggest two algorithms for solving this problem. One algorithm is based on th...

BACKGROUND Most HIV-seropositive subjects in western countries receive highly active antiretroviral therapy (HAART). Although many aspects of their health have been studied, little is known about their vestibular and balance function. The goals of this study were to determine the prevalences of vestibular and balance impairments among HIV-seropositive and comparable seronegative men and women a...

We present and solve optimality equations for the 2-player, jeopardy dice game Farkle (a.k.a. Dix Mille, Ten Thousand). For fairest play, we recommend 200 compensation points at the beginning of the game for the second player. We then compute the strategy that maximizes expected score, demonstrate a means for replicating such play with mental mathematics, and augment this method so as to enable...

UNLABELLED Benign Paroxysmal Positional Vertigo is one of the most common causes of dizziness. Its characteristic clinical profile is dizziness at head movements. The main diagnostic maneuver of posterior canal Benign Paroxysmal Positional Vertigo is the Dix-Hallpike test. If the maneuver is positive (vertigo and/or nystagmus), the physician can perform the Epley maneuver on the injured side. ...

Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. APC downregulates Wnt signalling by enabling Axin to promote the degradation of the Wnt signalling effector β-catenin (Armadillo in flies). This depends on Axin's DIX domain whose polymerization allows it to form dynamic protein assemblies ('degradasomes'). Axin is in...

We consider a Riemannian manifold, (M, g), of dimension n with boundary ∂M . We analyze the inverse problem, originally formulated by Dix [4], of reconstructing g from boundary measurements associated with the single scattering of seismic waves on this manifold. The measurements determine the shape operator on the boundary. We develop an explicit reconstruction procedure involving the solution ...