نتایج جستجو برای: dj 1
تعداد نتایج: 2753812 فیلتر نتایج به سال:
[Purpose] Strength-duration (SD) curves are used in electrical diagnosis by physiotherapists to confirm muscle degeneration. However, the usefulness of SD curves in comparing muscle degeneration in DJ-1 homozygous knockout (DJ-1(-/-)) and wild-type mice (DJ-1(+/+)) is not yet fully understood. The electrical properties of the gastrocnemius muscles of DJ-1(-/-) and DJ-1(+/+) mice were compared i...
The manifestations of Parkinson's disease are caused by reduced dopaminergic innervation of the striatum. Loss-of-function mutations in the DJ-1 gene cause early-onset familial parkinsonism. To investigate a possible role for DJ-1 in the dopaminergic system, we generated a mouse model bearing a germline disruption of DJ-1. Although DJ-1(-/-) mice had normal numbers of dopaminergic neurons in th...
Reference: Belter CW, Seidel DJ. 2013. A bibliometric analysis of climate engineering research. Wiley Interdisciplinary Reviews: Climate Change 4(5):417-427. doi:10.1002/wcc.229 Note: Opinions expressed in this poster are solely those of the authors and do not necessarily reflect those of NOAA, the Department of Commerce, or the US Government. Use of products in this analysis do not constitute ...
Loss-of-function mutations in the PARK7/DJ-1 gene cause early onset autosomal-recessive Parkinson disease. DJ-1 has been implicated in protection of neurons from oxidative stress and in regulation of transcriptional activity. However, whether there is a relationship between the subcellular localization of DJ-1 and its function remains unknown. Therefore, we examined the subcellular localization...
BACKGROUND The development of oral squamous cell carcinoma (OSCC) is a multistep process that involves in both genetic alterations and epigenetic modifications. DJ-1, a negative regulator of tumor suppressor PTEN, functions as an oncogene in many types of cancers. However, its role in OSCC is poorly known. METHODS Immunohistochemical staining and Western blotting were performed to evaluate th...
Mutations in the DJ-1 gene cause early-onset autosomal recessive Parkinson's disease (PD), although the role of DJ-1 in the degeneration of dopaminergic neurons is unresolved. Here we show that the major interacting-proteins with DJ-1 in dopaminergic neuronal cells are the nuclear proteins p54nrb and pyrimidine tract-binding protein-associated splicing factor (PSF), two multifunctional regulato...
The loss of dopaminergic neurons in the substantia nigra is the pathological hallmark of Parkinson's disease (PD). While the etiology of sporadic PD remains elusive, an inherited form of early-onset familial PD is linked to mutations of DJ-1. To understand the biological function of DJ-1 and its relevance to the pathogenesis of PD, we investigated the function of DJ-1 using Drosophila. Drosophi...
هدف از مطالعه حاضر، مقایسه اثر دو روش تمرین پلایومتریک (depth jump [dj] و countermovement jump [cmj]) در ماسه بر عملکرد جسمانی و تغییرات الکترومایوگرافی دانشجویان غیر ورزشکار بود. بدین منظور، 30 دانشجوی مرد غیر ورزشکار بصورت داوطلبانه در این پژوهش شرکت کردند. بعد از انجام پیش آزمون و همسان سازی بر اساس پرش ارتفاع، آزمودنی ها بصورت تصادفی به سه گروه: dj؛ 10=n سن 8/0±7/20 سال، وزن 9/8±2/75 کیلوگر...
هدف: هدف از این مطالعه بررسی تاثیر dj-1 بر افزایش بقای سلولهای دوپامین ساز در برابر سمیت پارکینسونی میباشد. مواد و روشها: ابتدا لنتی ویروسهای نوترکیب ناقل توام ژن های dj-1 و گزارشگر jred تولید شده و برای آلوده سازی سلولها استفاده شدند. بدین منظور سه پلاسمید لنتی ویروسی بهنامهای ناقل، بسته بندی و غشا برای ترانسفکشن سلولهای hek-293t بهعنوان رده سلولی مولد ویروس بهکار برده شدند. محیط ...
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