نتایج جستجو برای: dmpc cpg odn nanoliposomes

تعداد نتایج: 15489  

Journal: :Journal of virology 2003
Ali M Harandi Kristina Eriksson Jan Holmgren

Unmethylated CpG dinucleotides in bacterial DNA or synthetic oligodeoxynucleotides (ODNs) are known as potent activators of the immune system and inducers of several Th1-associated immunomodulatory cytokines. We therefore investigated whether such a CpG-containing ODN (CpG ODN) given mucosally in the female genital tract could enhance innate immunity and protect against genital herpes infection...

2015
Yi Xu Peter Claiden Yufang Zhu Hiromi Morita Nobutaka Hanagata

In this study, we proposed to modify mesoporous silica nanoparticles (MSNs) with 3-aminopropyltriethoxysilane (NH2-TES), aminoethylaminopropyltriethoxysilane (2NH2-TES) and 3-[2-(2-aminoethylamino)ethylamino] propyl-trimethoxysilane (3NH2-TES) for binding of cytosine-phosphate-guanosine oligodexynucleotides (CpG ODN), and investigated the effect of different amino groups of MSNs on the CpG ODN ...

Alireza Salek Moghadam Reza Falak Tahereh Mousavi,

Background: There are many therapeutic methods for allergic conditions. CpG oli-gonucleotides play a critical role in immunity via the augmentation of Th1 and suppres-sion of Th2 responses. Objective: In the present study we aimed to estimate the effec-tiveness of intranasal administration of CpG ODN plus Chenopodium album allergen in allergic asthma compared with the administration of allergen...

Journal: :The Journal of biological chemistry 2012
Xichun Pan Junjie Yue Guofu Ding Bin Li Xin Liu Xinchuan Zheng Mengchen Yu Jun Li Weiwei Jiang Chong Wu Jiang Zheng Hong Zhou

TLR9 is a receptor for sensing bacterial DNA/CpG-containing oligonucleotides (CpG ODN). The extracellular domain (ECD) of human TLR9 (hTLR9) is composed of 25 leucine-rich repeats (LRR) contributing to the binding of CpG ODN. Herein, we showed that among LRR2, -5, -8, and -11, LRR11 of hTLR9 had the highest affinity for CpG ODN followed by LRR2 and -5, whereas LRR8 had almost no affinity. In vi...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
W Nicholas Haining Jeffrey Davies Holger Kanzler Linda Drury Thomas Brenn John Evans Jill Angelosanto Steven Rivoli Kate Russell Suzanne George Paul Sims Donna Neuberg Xiaochun Li Jeffrey Kutok Jeffrey Morgan Patrick Wen George Demetri Robert L Coffman Lee M Nadler

PURPOSE CpG oligodeoxynucleotides (CpG-ODN) are being investigated as cancer vaccine adjuvants because they mature plasmacytoid dendritic cells (PDC) into potent antigen-presenting cells. CpG-ODN also induce PDC to secrete chemokines that alter lymphocyte migration. Whether CpG-ODN TLR signals enhance antigen-specific immunity and/or trafficking in humans is unknown. EXPERIMENTAL DESIGN We co...

Journal: :Vaccine 2007
Mahmoud R Jaafari Ali Badiee Ali Khamesipour Afshin Samiei Dina Soroush Masoumeh Tavassoti Kheiri Farzaneh Barkhordari W Robert McMaster Fereidoun Mahboudi

CpG oligodeoxynucleotides (CpG ODN) are known to be a potent immunoadjuvant for a wide range of antigens. The aim of this study was to evaluate the role of CpG ODN co-encapsulated with rgp63 antigen in cationic liposomes (Lip-rgp63-CpG ODN) in immune response enhancement and protection in BALB/c mice against leishmaniasis. Lip-rgp63-CpG ODN prepared by using dehydration-rehydration vesicle (DRV...

Journal: :Journal of leukocyte biology 2008
Paola Secchiero Elisabetta Melloni Mario Tiribelli Arianna Gonelli Giorgio Zauli

We have investigated the effect of combined treatment with CpG-oligodeoxynucleotide (CpG-ODN) plus Nutlin-3, a small molecule inhibitor of the murine double minute 2/p53 interaction, on the immune activation, cell cycle progression, and apoptosis of peripheral blood B chronic lymphocytic leukemia (B-CLL) cells. CpG-ODN induced a robust up-regulation of immune activation markers (CD54, CD69, CD8...

Journal: :The Journal of antimicrobial chemotherapy 2010
Shraddha A Sane Nishi Shakya W Haq Suman Gupta

OBJECTIVES To evaluate the combination of CpG oligodeoxynucleotide (CpG ODN) and miltefosine for the treatment of experimental visceral leishmaniasis (VL). METHODS The experiments were carried out using BALB/c mice and hamsters, infected with Leishmania donovani. CpG ODN was administered at various doses by the intraperitoneal (ip) route. The dose of CpG ODN (1 nM/single dose) showing best an...

Journal: :Journal of immunology 2002
Barun K Choudhury James S Wild Rafeul Alam Dennis M Klinman Istvan Boldogh Nilesh Dharajiya William J Mileski Sanjiv Sur

DNA containing unmethylated CpG motifs is intrinsically immunostimulatory, inducing the production of a variety of cytokines and chemokines by immune cells. The strong Th1 response triggered by CpG oligodeoxynucleotide (ODN) inhibits the development of Th2-mediated allergic asthma in mice. This work documents that CpG ODN-induced IL-12 production plays a critical role in this process, because i...

Journal: :Journal of immunology 2004
Troy J Kemp Jill M Moore Thomas S Griffith

CpG-containing oligodeoxynucleotides (CpG ODN) have broad-ranging immunostimulatory effects, including the generation of antitumor immune responses. Analysis of different CpG ODN have identified two classes: CpG-A ODN, which stimulate high levels of IFN-alpha production from plasmacytoid dendritic cells and weakly activate B cells, and CpG-B ODN, which strongly activate B cells but stimulate lo...

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