Purpose. This study was designed to determine the efficacy and mechanisms of radioprotection by the combination of gamma-tocotrienol (GT3) and pentoxifylline (PTX) against acute radiation injury. Materials and Methods. Post-irradiation survival was monitored to determine the most efficacious dose and time of administration of PTX. Dose reduction factor (DRF) was calculated to compare the radiop...

Since the early times, radioprotection has been focused on the human being. Currently this approach has changed, being now also necessary to take care of the protection of the environment from unwanted effects of ionizing radiation. To this end, several institutions (UNSCEAR, ICRP, IAEA, DOE, ACRP) and consortia of institutions (FASSET, ERICA) have established procedures in order to protect the...

The Tousled-like kinases (TLKs) function in processes of chromatin assembly, including replication, transcription, repair, and chromosome segregation. TLKs interact specifically (and phosphorylate) with the chromatin assembly factor Asf1, a histone H3-H4 chaperone, histone H3 itself at Ser10, and also Rad9, a key protein involved in DNA repair and cell cycle signaling following DNA damage. Thes...

UNLABELLED This article pioneers a study into the influence of the high-Z component of nanoparticles on the efficacy of radioprotection some nanoparticles offer to exposed cells irradiated with X-rays. We reveal a significant decrease in the radioprotection efficacy for cells exposed to CeO2 nanoparticles and irradiated with 10 MV and 150 kVp X-rays. In addition, analysis of the 150 kVp surviva...

Background: DNA damage is one of the major consequences of radiation exposure onto the biological systems. A series of compounds including flavanoids were found to render DNA protection against radiation damage. In this study we elucidated the potential of rutin and rutin hydrate to protect plasmid DNA against damage induced by irradiation. Materials and Methods: DPPH and hydroxyl radical scave...

M. BENSIDHOUM, A. CHAPEL, S. FRANCOIS ,C. DEMARQUAY, C. MAZURIER, L. FOUILLARD, S. BOUCHET, JM. BERTHO, P. GOURMELON, J. AIGUEPERSE, P. CHARBORD, NC. GORIN, D. THIERRY, M. LOPEZ (1) : Laboratoire de Thérapie Cellulaire et de Radioprotection Accidentelle, Faculté de Médecine Saint Antoine et IRSN, EA 1638 et Inserm U76.– (2) : Institut de Radioprotection et de Sureté Nucléaire, Fontenay Aux Rose...

The radiobiological effects of highly-charged-ion beams are of interest for tumortherapy and for radioprotection in space. In tumor therapy, high-energy protons and carbon ions exhibit an inverse dose profile, i.e. an increase of energy deposition with penetration depth. This allows a greater tumor dose for protons and carbon ions than for photons. In addition, for the heavier carbon ions, this...

1 IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U896, Montpellier, F-34298, France; Université Montpellier1, Montpellier, F34298, France; CRLC Val d’Aurelle Paul Lamarque, Montpellier, F-34298, France; 2 CRLC Val d’Aurelle-Paul Lamarque, F-34298 Montpellier, France; 3 Service de Médecine Nucléaire, CHU de Nîmes, Nîmes F-30029, France; 4 Direct...