a growing number of observational and epidemiological studies have suggested that mental illness, in particular mood disorders, is associated with decreased dietary intake and/or cellular abundance of omega-3 polyunsaturated fatty acids (pufa). this has prompted researchers to test the efficacy of omega-3 pufa in a range of different psychiatric disorders. we have critically reviewed the double...

objective: type 2 diabetes mellitus (dm-2) is a chronic and progressive metabolic disorder known as a serious threatening condition in the individual and society. type 2 diabetes mellitus is known as the major cause of cardiovascular diseases (cvd). contradictory evidences about the effect of omega-3 fatty acids on cvd risk factors, particularly hypertension. the aim of this study was to determ...

Neuroprostanes are prostaglandin-like compounds produced by free radical-induced peroxidation of docosahexaenoic acid, which is highly enriched in the brain. We previously described the formation of highly reactive gamma-ketoaldehydes (isoketals) as products of the isoprostane pathway of free radical-induced peroxidation of arachidonic acid. We therefore explored whether isoketal-like compounds...

The purpose of this study was to determine whether the formation of docosahexaenoic acid in human cells occurs through a pathway that involves 24-carbon n-3 fatty acid intermediates and retroconversion. Normal human skin fibroblasts synthesized radiolabeled docosahexaenoic acid from [1-(14)C]18:3n-3, [3-(14)C]22:5n-3, [3-(14)C]24:5n-3, and [3-(14)C]24:6n-3. The amount of docosahexaenoate formed...

BACKGROUND Chronic exposure to the glucocorticoid hormone corticosterone exerts cellular stress-induced toxic effects that have been associated with neurodegenerative and psychiatric disorders. Docosahexaenoic acid is a polyunsaturated fatty acid that has been shown to be of benefit in stress-related disorders, putatively through protective action in neurons. METHODS We investigated the prote...

The experiment was conducted to investigate the effects of artemia enriched with lipid emulsions containing highly unsaturated fatty acids on growth and survival of juvenile freshwater crayfish Astacus leptodactylus. Juvenile crayfish were fed artemia enriched with commercial emulsions (red pepper and olio ω3) and un-enriched artemia (control). The highest eicosapentaenoic acid (EPA) level was ...

The experiment was conducted to investigate the effects of artemia enriched with lipid emulsions containing highly unsaturated fatty acids on growth and survival of juvenile freshwater crayfish Astacus leptodactylus. Juvenile crayfish were fed artemia enriched with commercial emulsions (red pepper and olio ω3) and un-enriched artemia (control). The highest eicosapentaenoic acid (EPA) level was ...

The total lipid content and composition of fatty acids of the liver and muscles of wild and cultured male and female Acanthopagrus latus were determined by gas-liquid chromatography. There were quantitative differences between individual fatty acids in the tissues investigated depending on sex and location. In all the samples studied, sex and location considered, the principle saturated fatty a...

Docosahexaenoic acid is a fatty found naturally in plants oil, fish meat, seafood flaxseed, algae, and egg yolk. It one of the long-chain unsaturated acids that are important for human biochemistry. As an component grey matter, docosahexaenoic subject to intense research field neurodevelopmental study. needed mainly third trimester pregnancy optimal foetal brain growth mother’s intake known be ...

A Brownian dynamics (BD) simulation of two unsaturated molecules, oleic and docosahexaenoic acid, in an environment that reproduces a cellular membrane, is presented. The results of the simulations, performed using mean-field potentials, were calibrated with experimental results obtained for oleic acid in a cellular membrane. The agreement between simulation and experimental results is excellen...