In the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (WSS) on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. The opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). The first group exposed to WSS in the pr...

Dopamine D4 receptors (D4R) are localized in the globus pallidus (GP), but their function remains unknown. In contrast, dopamine D2 receptor activation hyperpolarizes medium spiny neurons projecting from the striatum to the GP and inhibits GABA release. However, using slice preparations from D2R-deficient [D2 knock-out (D2KO)] mice, we found that dopamine inhibited GABA(A)-receptor-mediated cur...

Direct acting dopamine agonists are generally less effective than levodopa in relieving symptoms of Parkinson's disease. In an attempt to quantitate and explain this situation, the acute motor responses to intravenous injections of the dopamine agonist, (-)-N-n-propyl-norapomorphine hydrochloride (NPA), were compared with those of the dopamine precursor, levodopa. At optimum dose levels, the ac...

A 41-year-old man with an unremarkable medical history aspirated gastric contents during an esophagogastrectomy with intrathoracic gastroesophageal anastomosis for adeno carcinoma of the esophagus. After surgery, he could not be weaned from mechanical ventilation. He was therefore trans ferred to the intensive care unit for ventilatory support. Follow-up chest x-ray films and cultures of sputum...

Yawning and spontaneous blink rate (SBR) are two physiological reflexes which have been incompletely examined but one neurobiological step of these two behaviours seems, at least in part, dopamine-dependent. The reference dopaminergic agonist, apomorphine hydrochloride (0.5, 1, and 2 micrograms kg-1 s.c.), was compared with a placebo in a double-blind latin-square design, and was shown to induc...

Developing simple, sensitive and selective sensing systems for dopamine is important due to its biological significance. In this work, a silver nanoparticles-modified carbon paste electrode (AgNPs-CPE) has been constructed and used to detect of dopamine (DA) in the simultaneous presence of ascorbic acid (AA) and uric acid (UA) at neutral pH 7.0 by cyclic voltammetry. The modified electrode show...

developing simple, sensitive and selective sensing systems for dopamine is important due to its biological significance. in this work, a silver nanoparticles-modified carbon paste electrode (agnps-cpe) has been constructed and used to detect of dopamine (da) in the simultaneous presence of ascorbic acid (aa) and uric acid (ua) at neutral ph 7.0 by cyclic voltammetry. the modified electrode show...

5 Bergman, H., Wichmann, T. and DeLong, M. R. (1990) Science 249, 1436-1438 6 Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J. and Sibley, D. R. (1990) Science 250, 1429-1432 7 Kaur, S., Starr, M. S. and Starr, B. S. (1994) J. Neural Transm. 8, 107-1 16 8 Klockgether, T. and Turski, L. (1990) Ann. Neurol. 28, 539-546 9 Robertson, G. S. and Robertson, H. A. (198...

A dopamine-imprinted polymer (MIP) was prepared in aqueous methanol solution at 60(o)C by free-radical cross-linking polymerization of methacrylic acid in the presence of ethylene glycol dimethacrylate as the cross-linker and dopamine hydrochloride as the template molecule. Its ability to isolate dopamine was evaluated as the basis of a solid phase extraction procedure and compared with that of...