نتایج جستجو برای: dorsal root ganglion
تعداد نتایج: 195196 فیلتر نتایج به سال:
OBJECTIVE To describe the location of the dorsal root ganglion in relation to the intervertebral disc, including the "triangular" safety zone for minimally invasive surgery in the lumbar spine. METHODS Eight adult cadavers were dissected bilaterally in the lumbar region, using a posterolateral approach, so as to expose the L3L4 and L4L5 spaces, thereby obtaining measurements relating to the s...
Pharmacotherapy of neuropathic pain is still challenging. Our earlier work indicated an analgesic effect dimethyl trisulfide (DMTS), which was mediated by somatostatin released from nociceptor nerve endings acting on SST4 receptors. Somatostatin release occurred due to TRPA1 ion channel activation. In the present study, we investigated DMTS in evoked partial ligation sciatic mice. Expression mR...
Sympathoexcitation is associated with ventricular arrhythmogenesis. The aim of this study was to determine the role of thoracic dorsal root afferent neural inputs to the spinal cord in modulating ventricular sympathetic control of normal heart electrophysiology. We hypothesize that dorsal root afferent input tonically modulates basal and evoked efferent sympathetic control of the heart. A 56-el...
The P2X(3) receptor is a ligand-gated cation channel that is activated by extra cellular adenosine triphosphate (ATP) found in the dorsal root, trigeminal and nodose ganglia. It is one of the receptors transmitting nociceptive information of injuries and inflammation of the periphery by endogenous ATP released from damaged cells. The present study was performed in order to evaluate if there was...
The Na(v)1.7 sodium channel is preferentially expressed in nocioceptive dorsal root ganglion and sympathetic ganglion neurons. Gain-of-function mutations in Na(v)1.7 produce the nocioceptor hyperexcitability underlying inherited erythromelalgia, characterized in most kindreds by early-age onset of severe pain. Here we describe a mutation (Na(v)1.7-G616R) in a pedigree with adult-onset of pain i...
Dorsal root ganglion stimulation approval by the Food and Drug Administration: advice on evolving the process Timothy R. Deer & Jason E. Pope To cite this article: Timothy R. Deer & Jason E. Pope (2016) Dorsal root ganglion stimulation approval by the Food and Drug Administration: advice on evolving the process, Expert Review of Neurotherapeutics, 16:10, 1123-1125, DOI: 10.1080/14737175.2016.12...
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