conclusions evaluation of iranian traditional dosage forms like vaginal and rectal types could be an attractive topic of research and the current study can briefly represent the iranian traditional pharmaceutical knowledge on vaginal and rectal drug delivery. objectives the aim of this study is the investigation about iranian traditional pharmaceutical dosage forms of vaginal and rectal medicat...

Gene dosage effects have emerged as playing a central role in the pathogenesis of polycystic kidney disease. Yet, how gene dosage can ultimately have an impact on the formation of kidney cysts remains unknown. In this commentary we review the evidence for the role of gene dosage effects versus the "2-hit" mutation model in polycystic kidney disease (PKD), and also discuss how gene networks may ...

Copy-number alterations are widespread in animal and plant genomes, but their immediate impact on gene expression is still unclear. In animals, copy-number alterations usually exhibit dosage effects, except for sex chromosomes which tend to be dosage compensated. In plants, genes within small duplications (<100 kb) often exhibit dosage-dependent expression, whereas large duplications (>50 Mb) a...

conclusions zolpidem dependency and withdrawal seizure can occur with a dosage under last reported doses. therefore, possibility of mentioned problems cannot be excluded at any dosage and physicians should pay more attention to potential of zolpidem to create these adverse effects. introduction zolpidem is a short acting inducer of sleep and thought to lack benzodiazepine properties such as anx...

Therapy and the Risk of Cardiovascular Disease To the Editor: In their interesting study, Koh et al demonstrated that lower dosage of oral conjugated equine estrogen (CEE) eliminated the adverse effects of conventional dosage of CEE on markers of vascular inflammation and coagulation, in addition to preserving the favorable effects of estrogen on endothelial function.1 Similar to their report, ...

Investigations were carried out on coal tailings by conventional cell and column flotation techniques. Tests were conducted to assess processing coal tailings of Alborz Markazi coal washing plant in Iran by column flotation. The effects of reagent type/dosage were investigated with conventional flotation and their results were used in the performance of column flotation. Also the effects of the...

BACKGROUND To study the link between the dosage of several antipsychotics and the prescription of antiparkinsonians in an observational study. METHODS In the context of a national naturalistic prospective observational study, a database containing all the prescriptions from 100 French psychiatrists during the year 2002 was analysed. The inclusion criteria were a diagnosis of schizophrenia or ...