Toxicologically-based quantitative risk assessment is concerned with estimating human risks based upon experimental data linking an environmental agent to a known outcome (tumor incidence, acute toxicity, etc.). For dichotomous outcomes dose-response curves are modeled as complex functions of dose which often require specialized software to estimate. The SAS procedure NLMIXED readily allows for...

Mammographic breast density is a strong risk factor for breast cancer. Studies on imaging dose in mammography have primarily focused on imaging quality and diagnostic accuracy, while little work has been done on understanding its effect on the estimation of breast density. Studies on the effect of dose on mammographic density estimation can be useful in dose reduction for the purpose of density...

Introduction: Hypothyroidism is one of the frequent side effects of radiotherapy of head and neck cancers, breast cancer, and Hodgkin's lymphoma. It is recommended to estimate the normal tissue complication probability of thyroid gland using radiobiological modeling during treatment planning. Moreover, the use of artificial neural network is also proposed as a new method for t...