A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.

Human beta-interferon stimulates a 4-fold increase in the concentration of diacyglycerol and a 2-fold increase in the concentration of inositol monophosphate in Daudi (human B-lymphoblastoid) cells within 30 sec of exposure of the cells to interferon. The increase in diacylglycerol and in inositol monophosphate is transient and the concentrations of these compounds decrease to basal levels with...

alpha-interferon therapy has been approved for treatment of chronic hepatitis c and b. candidates for treatment are patients with well-compensated liver disease and histologic evidences of chronic hepatitis who have demonstrated abnormal aminotransferase levels for more than 6 months. from 30 patients with chronic hepatitis with diseases prolonged more than 6 months, we selected only 16 patient...

BACKGROUND Maintenance therapy with interferon-alpha after high-dose treatment with stem cell support in multiple myeloma has been intensively debated. In this study, we evaluated the response to treatment with interferon-alpha in relation to genetic variation in genes related to inflammation. DESIGN AND METHODS In a retrospective study of 296 patients with multiple myeloma undergoing high-do...

bronchiolitis has been known as one of the pathological features of lung injuries in mustard gas exposed patients the purpose of this research was to evaluate the efficacy of interferon gamma-1b on the lung function in mustard gas exposed patients with bronchiolitis. in multicenter research interferon gamma-1b was effective in pulmonary fibrosis with unknown reason, but assessment of effect of ...

Mammalian cells utilize a wide spectrum of pathways to antagonize the viral replication. These are typically regulated by antiviral proteins and can be constitutively expressed but also exacerbated interferon induction. A myriad interferon-stimulated genes (ISGs) have been identified in mounting broad-spectrum responses. Members interferon-induced transmembrane (IFITM) family unique among these...

Background. Current treatment of chronic hepatitis C with pegylated interferon and ribavirin has the ability to eliminate viral infection in about half of the patients treated. Therapeutic options, for those with remaining chronic hepatitis, will remain limited until novel antivirals become available in the future. Consensus interferon is currently available and has demonstrated clinical effica...

Different procedures have been used in attempts to increase the production of interferon by polyriboinosinic acid-polyribocytidylic acid (poly [rI].poly [rC]) in mice: simultaneous injection of lead acetate, cycloheximide, or actinomycin D and prior injection of Freund's adjuvant, chlorite-oxidized oxyamylose (COAM), endotoxin, or Brucella abortus. In the experimental conditions tested, lead ac...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: hepatitis d virus (hdv) infection is characterized by rapidly progressive liver disease with adverse prognosis in most patients. although interferon is the only approved anti-hdv therapy, evidence regarding the efficacy and safety of its various regimens is either old or scattered. materials and methods: we sea...

Correspondence to: Dr S Iino, Institute of Medical Science, School of Medicine, St Marianna University, 2-16-11 Sugao, Miyamae-ku, Kawasaki City, Japan. Abstract One hundred and twenty six patients were enrolled in a study to assess the effect of different interferon alfa-2b treatment regimens on the rate ofincrease in alanine aminotransferase (ALT) activities after treatment. Results indicated...