نتایج جستجو برای: drug allergy
تعداد نتایج: 609923 فیلتر نتایج به سال:
Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs. Spontaneous reporting makes up the core data-generating system of pharmacovigilance, but there is a large under-estimation of allergy/hypersensitivity drug reactions. A specific database is therefore required for drug allergy and ...
Background: Drug-induced hypersensitivity syndrome (DIHS) can be associated with cytomegalovirus (CMV) infection, besides induced by drugs. We report a case of DIHS prolonged atypical clinical features and vasculitis precipitated drug allergy, CMV, other viral infections.
OBJECTIVE The aim of this study was to determine characteristics of drug allergy alert overrides, assess how often they lead to preventable adverse drug events (ADEs), and suggest methods for improving the allergy-alerting system. DESIGN Chart review was performed on a stratified random subset of all allergy alerts occurring during a 3-month period (August through October 2002) at a large aca...
What Is a Drug Allergy? Formally, a drug allergy is a clinically significant adverse reaction mediated by IgE that is reproducible on rechallenge. To cause a drug allergy, a drug must be an intact multivalent allergen, such as a protein with a molecular weight greater than 5000, or be able to haptenate an endogenous protein. Functionally, all drugs listed in the “drug allergy” section of a medi...
EDITORIAL article Front. Allergy, 19 September 2023Sec. Drug, Venom & Anaphylaxis Volume 4 - 2023 | https://doi.org/10.3389/falgy.2023.1278690
Drug-induced hypersensitivity reactions encompass a variety of different clinical phenotypes ranging from harmless rashes to fatal reactions. They can be classified into allergic (i.e. drug allergy) and non-allergic hypersensitivity). Drug allergies in turn either antibody (e.g. IgE) or T cell-mediated. One the diagnostic tools for vitro detection allergy is lymphocyte transformation test (LTT)...
BACKGROUND Unconfirmed beta-lactam allergy is a significant public health problem because of the limitations it imposes in drug selection. In this study, we aimed to evaluate patients referred for beta-lactam allergy to determine the frequency of confirmed beta-lactam allergy and identify some risk factors. METHODS In a prospective cohort study, all referred patients to Immunology, Asthma and...
The authors present the in vivo investigation options drug allergy. In suspicion of induced hypersensitivity reaction prick testing, intradermal testing and patch are recommended according to assumed immuno-mechanism. If these examinations negative, next step is provocation test, which gold standard diagnosis We summarize methods, indications contraindications evaluationof each focusing on issu...
A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions. DPTs are performed under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself. DPT is sometimes termed controlled challenge or reexposure (1), drug challenge (2), graded (2) or increm...
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